Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The ana...

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Autores principales: Menna, Marialuisa, Aiello, Anna, D’Aniello, Filomena, Fattorusso, Ernesto, Imperatore, Concetta, Luciano, Paolo, Vitalone, Rocco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509532/
https://www.ncbi.nlm.nih.gov/pubmed/23203274
http://dx.doi.org/10.3390/md10112509
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author Menna, Marialuisa
Aiello, Anna
D’Aniello, Filomena
Fattorusso, Ernesto
Imperatore, Concetta
Luciano, Paolo
Vitalone, Rocco
author_facet Menna, Marialuisa
Aiello, Anna
D’Aniello, Filomena
Fattorusso, Ernesto
Imperatore, Concetta
Luciano, Paolo
Vitalone, Rocco
author_sort Menna, Marialuisa
collection PubMed
description An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.
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spelling pubmed-35095322012-12-10 Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine Menna, Marialuisa Aiello, Anna D’Aniello, Filomena Fattorusso, Ernesto Imperatore, Concetta Luciano, Paolo Vitalone, Rocco Mar Drugs Article An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10. MDPI 2012-11-09 /pmc/articles/PMC3509532/ /pubmed/23203274 http://dx.doi.org/10.3390/md10112509 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Menna, Marialuisa
Aiello, Anna
D’Aniello, Filomena
Fattorusso, Ernesto
Imperatore, Concetta
Luciano, Paolo
Vitalone, Rocco
Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_full Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_fullStr Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_full_unstemmed Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_short Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_sort further investigation of the mediterranean sponge axinella polypoides: isolation of a new cyclonucleoside and a new betaine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509532/
https://www.ncbi.nlm.nih.gov/pubmed/23203274
http://dx.doi.org/10.3390/md10112509
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