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Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis

Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacteri...

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Autores principales: Liu, Ling-Li, Xu, Ying, Han, Zhuang, Li, Yong-Xin, Lu, Liang, Lai, Pok-Yui, Zhong, Jia-Liang, Guo, Xian-Rong, Zhang, Xi-Xiang, Qian, Pei-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509536/
https://www.ncbi.nlm.nih.gov/pubmed/23203278
http://dx.doi.org/10.3390/md10112571
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author Liu, Ling-Li
Xu, Ying
Han, Zhuang
Li, Yong-Xin
Lu, Liang
Lai, Pok-Yui
Zhong, Jia-Liang
Guo, Xian-Rong
Zhang, Xi-Xiang
Qian, Pei-Yuan
author_facet Liu, Ling-Li
Xu, Ying
Han, Zhuang
Li, Yong-Xin
Lu, Liang
Lai, Pok-Yui
Zhong, Jia-Liang
Guo, Xian-Rong
Zhang, Xi-Xiang
Qian, Pei-Yuan
author_sort Liu, Ling-Li
collection PubMed
description Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
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spelling pubmed-35095362012-12-10 Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis Liu, Ling-Li Xu, Ying Han, Zhuang Li, Yong-Xin Lu, Liang Lai, Pok-Yui Zhong, Jia-Liang Guo, Xian-Rong Zhang, Xi-Xiang Qian, Pei-Yuan Mar Drugs Article Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. MDPI 2012-11-20 /pmc/articles/PMC3509536/ /pubmed/23203278 http://dx.doi.org/10.3390/md10112571 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liu, Ling-Li
Xu, Ying
Han, Zhuang
Li, Yong-Xin
Lu, Liang
Lai, Pok-Yui
Zhong, Jia-Liang
Guo, Xian-Rong
Zhang, Xi-Xiang
Qian, Pei-Yuan
Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
title Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
title_full Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
title_fullStr Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
title_full_unstemmed Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
title_short Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
title_sort four new antibacterial xanthones from the marine-derived actinomycetes streptomyces caelestis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509536/
https://www.ncbi.nlm.nih.gov/pubmed/23203278
http://dx.doi.org/10.3390/md10112571
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