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Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacteri...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509536/ https://www.ncbi.nlm.nih.gov/pubmed/23203278 http://dx.doi.org/10.3390/md10112571 |
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author | Liu, Ling-Li Xu, Ying Han, Zhuang Li, Yong-Xin Lu, Liang Lai, Pok-Yui Zhong, Jia-Liang Guo, Xian-Rong Zhang, Xi-Xiang Qian, Pei-Yuan |
author_facet | Liu, Ling-Li Xu, Ying Han, Zhuang Li, Yong-Xin Lu, Liang Lai, Pok-Yui Zhong, Jia-Liang Guo, Xian-Rong Zhang, Xi-Xiang Qian, Pei-Yuan |
author_sort | Liu, Ling-Li |
collection | PubMed |
description | Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. |
format | Online Article Text |
id | pubmed-3509536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-35095362012-12-10 Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis Liu, Ling-Li Xu, Ying Han, Zhuang Li, Yong-Xin Lu, Liang Lai, Pok-Yui Zhong, Jia-Liang Guo, Xian-Rong Zhang, Xi-Xiang Qian, Pei-Yuan Mar Drugs Article Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. MDPI 2012-11-20 /pmc/articles/PMC3509536/ /pubmed/23203278 http://dx.doi.org/10.3390/md10112571 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Liu, Ling-Li Xu, Ying Han, Zhuang Li, Yong-Xin Lu, Liang Lai, Pok-Yui Zhong, Jia-Liang Guo, Xian-Rong Zhang, Xi-Xiang Qian, Pei-Yuan Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis |
title | Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis |
title_full | Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis |
title_fullStr | Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis |
title_full_unstemmed | Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis |
title_short | Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis |
title_sort | four new antibacterial xanthones from the marine-derived actinomycetes streptomyces caelestis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509536/ https://www.ncbi.nlm.nih.gov/pubmed/23203278 http://dx.doi.org/10.3390/md10112571 |
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