Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses. Here we show that Niemann-Pick C1-like1 (NPC1L1), an NPC1 paralog and hepatitis C virus entry factor, lacks...

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Detalles Bibliográficos
Autores principales: Krishnan, Anuja, Miller, Emily Happy, Herbert, Andrew S., Ng, Melinda, Ndungo, Esther, Whelan, Sean P., Dye, John M., Chandran, Kartik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509659/
https://www.ncbi.nlm.nih.gov/pubmed/23202491
http://dx.doi.org/10.3390/v4112471

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