Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor

Antibiotic treatment may fail to protect individuals, if not started early enough, after infection with Bacillus anthracis, due to the continuing activity of toxins that the bacterium produces. Stable and easily stored inhibitors of the edema factor toxin (EF), an adenylyl cyclase, could save lives...

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Detalles Bibliográficos
Autores principales: Schein, Catherine H., Chen, Deliang, Ma, Lili, Kanalas, John J., Gao, Jian, Jimenez, Maria Estrella, Sower, Laurie E., Walter, Mary A., Gilbertson, Scott R., Peterson, Johnny W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509708/
https://www.ncbi.nlm.nih.gov/pubmed/23202316
http://dx.doi.org/10.3390/toxins4111288

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