Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Drosophila Photoreceptor Neurons

The mechanisms of cell cycle exit by neurons remain poorly understood. Through genetic and developmental analysis of Drosophila eye development, we found that the cyclin-dependent kinase-inhibitor Roughex maintains G1 cell cycle exit during differentiation of the R8 class of photoreceptor neurons. T...

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Detalles Bibliográficos
Autores principales: Ruggiero, Robert, Kale, Abhijit, Thomas, Barbara, Baker, Nicholas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510051/
https://www.ncbi.nlm.nih.gov/pubmed/23209426
http://dx.doi.org/10.1371/journal.pgen.1003049

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