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Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study
Troponin C (TnC) is implicated in the initiation of myocyte contraction via binding of cytosolic [Image: see text] and subsequent recognition of the Troponin I switch peptide. Mutations of the cardiac TnC N-terminal regulatory domain have been shown to alter both calcium binding and myofilament forc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510055/ https://www.ncbi.nlm.nih.gov/pubmed/23209387 http://dx.doi.org/10.1371/journal.pcbi.1002777 |