Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

Autosomal Dominant Polycystic Kidney Disease (ADPKD; MIM ID's 173900, 601313, 613095) leads to end-stage kidney disease, caused by mutations in PKD1 or PKD2. Inactivation of Pkd1 before or after P13 in mice results in distinct early- or late-onset disease. Using a mouse model of ADPKD carrying...

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Detalles Bibliográficos
Autores principales: Menezes, Luis F., Zhou, Fang, Patterson, Andrew D., Piontek, Klaus B., Krausz, Kristopher W., Gonzalez, Frank J., Germino, Gregory G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510057/
https://www.ncbi.nlm.nih.gov/pubmed/23209428
http://dx.doi.org/10.1371/journal.pgen.1003053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510057/
https://www.ncbi.nlm.nih.gov/pubmed/23209428
http://dx.doi.org/10.1371/journal.pgen.1003053

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