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A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1

INTRODUCTION: Traditional clinical trials in psoriasis exclude a significant proportion of patients with complex disease and comorbidities. A consensus panel of 14 experts in the field of psoriasis was formed to conduct a Delphi method exercise to identify difficult-to-treat psoriasis clinical scena...

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Autores principales: Strober, Bruce E., Clay Cather, Jennifer, Cohen, David, Crowley, Jeffrey J., Gordon, Kenneth B., Gottlieb, Alice B., Kavanaugh, Arthur F., Korman, Neil J., Krueger, Gerald G., Leonardi, Craig L., Schwartzman, Sergio, Sobell, Jeffrey M., Solomon, Gary E., Young, Melodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare Communications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510391/
https://www.ncbi.nlm.nih.gov/pubmed/23205324
http://dx.doi.org/10.1007/s13555-012-0001-y
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author Strober, Bruce E.
Clay Cather, Jennifer
Cohen, David
Crowley, Jeffrey J.
Gordon, Kenneth B.
Gottlieb, Alice B.
Kavanaugh, Arthur F.
Korman, Neil J.
Krueger, Gerald G.
Leonardi, Craig L.
Schwartzman, Sergio
Sobell, Jeffrey M.
Solomon, Gary E.
Young, Melodie
author_facet Strober, Bruce E.
Clay Cather, Jennifer
Cohen, David
Crowley, Jeffrey J.
Gordon, Kenneth B.
Gottlieb, Alice B.
Kavanaugh, Arthur F.
Korman, Neil J.
Krueger, Gerald G.
Leonardi, Craig L.
Schwartzman, Sergio
Sobell, Jeffrey M.
Solomon, Gary E.
Young, Melodie
author_sort Strober, Bruce E.
collection PubMed
description INTRODUCTION: Traditional clinical trials in psoriasis exclude a significant proportion of patients with complex disease and comorbidities. A consensus panel of 14 experts in the field of psoriasis was formed to conduct a Delphi method exercise to identify difficult-to-treat psoriasis clinical scenarios and to rank treatment approaches. METHODS: The exercise consisted of both survey questionnaires and a live meeting to review and discuss current data (as of 2009, when the exercise was conducted) and arrive at a consensus for optimal treatment options. Seventy difficult treatment scenarios were identified, and the top 24 were selected for discussion at the live meeting. RESULTS: Six of the 24 discussed case scenarios are presented in this article (another five are presented in Part 2): (1) psoriasis with human papilloma virus-induced cervical or anogenital dysplasia; (2) concomitant psoriasis and systemic lupus erythematosus; (3) severe psoriatic nail disease causing functional or emotional impairment; (4) psoriasis therapies that potentially reduce cardiovascular morbidity and mortality; (5) older patients (≥65 years of age) with psoriasis; and (6) severe scalp psoriasis that is unresponsive to topical therapy. CONCLUSION: The Delphi exercise resulted in guidelines for practicing physicians to utilize when confronted with challenging patients with psoriasis.
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spelling pubmed-35103912012-11-30 A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1 Strober, Bruce E. Clay Cather, Jennifer Cohen, David Crowley, Jeffrey J. Gordon, Kenneth B. Gottlieb, Alice B. Kavanaugh, Arthur F. Korman, Neil J. Krueger, Gerald G. Leonardi, Craig L. Schwartzman, Sergio Sobell, Jeffrey M. Solomon, Gary E. Young, Melodie Dermatol Ther (Heidelb) Review INTRODUCTION: Traditional clinical trials in psoriasis exclude a significant proportion of patients with complex disease and comorbidities. A consensus panel of 14 experts in the field of psoriasis was formed to conduct a Delphi method exercise to identify difficult-to-treat psoriasis clinical scenarios and to rank treatment approaches. METHODS: The exercise consisted of both survey questionnaires and a live meeting to review and discuss current data (as of 2009, when the exercise was conducted) and arrive at a consensus for optimal treatment options. Seventy difficult treatment scenarios were identified, and the top 24 were selected for discussion at the live meeting. RESULTS: Six of the 24 discussed case scenarios are presented in this article (another five are presented in Part 2): (1) psoriasis with human papilloma virus-induced cervical or anogenital dysplasia; (2) concomitant psoriasis and systemic lupus erythematosus; (3) severe psoriatic nail disease causing functional or emotional impairment; (4) psoriasis therapies that potentially reduce cardiovascular morbidity and mortality; (5) older patients (≥65 years of age) with psoriasis; and (6) severe scalp psoriasis that is unresponsive to topical therapy. CONCLUSION: The Delphi exercise resulted in guidelines for practicing physicians to utilize when confronted with challenging patients with psoriasis. Springer Healthcare Communications 2012-03-17 /pmc/articles/PMC3510391/ /pubmed/23205324 http://dx.doi.org/10.1007/s13555-012-0001-y Text en © The Author(s) 2012 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Strober, Bruce E.
Clay Cather, Jennifer
Cohen, David
Crowley, Jeffrey J.
Gordon, Kenneth B.
Gottlieb, Alice B.
Kavanaugh, Arthur F.
Korman, Neil J.
Krueger, Gerald G.
Leonardi, Craig L.
Schwartzman, Sergio
Sobell, Jeffrey M.
Solomon, Gary E.
Young, Melodie
A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1
title A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1
title_full A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1
title_fullStr A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1
title_full_unstemmed A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1
title_short A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 1
title_sort delphi consensus approach to challenging case scenarios in moderate-to-severe psoriasis: part 1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510391/
https://www.ncbi.nlm.nih.gov/pubmed/23205324
http://dx.doi.org/10.1007/s13555-012-0001-y
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