Cargando…

Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone

INTRODUCTION: Inverse psoriasis is a rare form of psoriasis that affects between 3% and 7% of the patients with psoriasis. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. There are few evidence-based studies about the...

Descripción completa

Detalles Bibliográficos
Autores principales: Guglielmetti, Antonio, Conlledo, Rodrigo, Bedoya, Juliana, Ianiszewski, Francisco, Correa, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare Communications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510394/
https://www.ncbi.nlm.nih.gov/pubmed/23205337
http://dx.doi.org/10.1007/s13555-012-0015-5
_version_ 1782251458368897024
author Guglielmetti, Antonio
Conlledo, Rodrigo
Bedoya, Juliana
Ianiszewski, Francisco
Correa, Julio
author_facet Guglielmetti, Antonio
Conlledo, Rodrigo
Bedoya, Juliana
Ianiszewski, Francisco
Correa, Julio
author_sort Guglielmetti, Antonio
collection PubMed
description INTRODUCTION: Inverse psoriasis is a rare form of psoriasis that affects between 3% and 7% of the patients with psoriasis. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. There are few evidence-based studies about the treatment of intertriginous psoriasis involving genital skin folds. CASE PRESENTATION: The authors present a 42-year-old female patient with erythematous plaques in the vulva, groin, and perianal region. The patient had previously received a broad range of topical and systemic therapies that had to be discontinued due to ineffectiveness or side effects. She was treated with 100 mg dapsone daily for 10 months, showing a significant improvement of her cutaneous and mucous lesions. Complete clearance of psoriatic lesions was observed after 4 weeks of treatment. She has remained in remission for up to 2 years, using only topical therapy with tacrolimus 0.1% and calcipotriol. DISCUSSION: Genital psoriasis is a skin disease that causes great discomfort. It is important to include examination of the genital region and to adopt this conduct in daily clinical practice. Research in this field is still poor, making no discrimination between flexural and genital psoriasis, and is based on case series and expert opinion; therefore, empirical recommendations for the treatment of genital psoriasis remain. Dapsone has been shown to be an effective and convenient alternative for the treatment of inverse psoriasis in genital skin folds, which can provide effective control of the disease. Further studies are required to determine the efficacy and safety of current therapies, and to decide whether dapsone therapy should be considered in the management of this form of psoriasis when topical and other systemic agents are not effective.
format Online
Article
Text
id pubmed-3510394
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Springer Healthcare Communications
record_format MEDLINE/PubMed
spelling pubmed-35103942012-11-30 Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone Guglielmetti, Antonio Conlledo, Rodrigo Bedoya, Juliana Ianiszewski, Francisco Correa, Julio Dermatol Ther (Heidelb) Case Report INTRODUCTION: Inverse psoriasis is a rare form of psoriasis that affects between 3% and 7% of the patients with psoriasis. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. There are few evidence-based studies about the treatment of intertriginous psoriasis involving genital skin folds. CASE PRESENTATION: The authors present a 42-year-old female patient with erythematous plaques in the vulva, groin, and perianal region. The patient had previously received a broad range of topical and systemic therapies that had to be discontinued due to ineffectiveness or side effects. She was treated with 100 mg dapsone daily for 10 months, showing a significant improvement of her cutaneous and mucous lesions. Complete clearance of psoriatic lesions was observed after 4 weeks of treatment. She has remained in remission for up to 2 years, using only topical therapy with tacrolimus 0.1% and calcipotriol. DISCUSSION: Genital psoriasis is a skin disease that causes great discomfort. It is important to include examination of the genital region and to adopt this conduct in daily clinical practice. Research in this field is still poor, making no discrimination between flexural and genital psoriasis, and is based on case series and expert opinion; therefore, empirical recommendations for the treatment of genital psoriasis remain. Dapsone has been shown to be an effective and convenient alternative for the treatment of inverse psoriasis in genital skin folds, which can provide effective control of the disease. Further studies are required to determine the efficacy and safety of current therapies, and to decide whether dapsone therapy should be considered in the management of this form of psoriasis when topical and other systemic agents are not effective. Springer Healthcare Communications 2012-10-09 /pmc/articles/PMC3510394/ /pubmed/23205337 http://dx.doi.org/10.1007/s13555-012-0015-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Case Report
Guglielmetti, Antonio
Conlledo, Rodrigo
Bedoya, Juliana
Ianiszewski, Francisco
Correa, Julio
Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone
title Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone
title_full Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone
title_fullStr Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone
title_full_unstemmed Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone
title_short Inverse Psoriasis Involving Genital Skin Folds: Successful Therapy with Dapsone
title_sort inverse psoriasis involving genital skin folds: successful therapy with dapsone
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510394/
https://www.ncbi.nlm.nih.gov/pubmed/23205337
http://dx.doi.org/10.1007/s13555-012-0015-5
work_keys_str_mv AT guglielmettiantonio inversepsoriasisinvolvinggenitalskinfoldssuccessfultherapywithdapsone
AT conlledorodrigo inversepsoriasisinvolvinggenitalskinfoldssuccessfultherapywithdapsone
AT bedoyajuliana inversepsoriasisinvolvinggenitalskinfoldssuccessfultherapywithdapsone
AT ianiszewskifrancisco inversepsoriasisinvolvinggenitalskinfoldssuccessfultherapywithdapsone
AT correajulio inversepsoriasisinvolvinggenitalskinfoldssuccessfultherapywithdapsone