Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebus murinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebus murinus...

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Autores principales: Canron, Marie-Hélène, Perret, Martine, Vital, Anne, Bézard, Erwan, Dehay, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510464/
https://www.ncbi.nlm.nih.gov/pubmed/23205271
http://dx.doi.org/10.1038/srep00910
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author Canron, Marie-Hélène
Perret, Martine
Vital, Anne
Bézard, Erwan
Dehay, Benjamin
author_facet Canron, Marie-Hélène
Perret, Martine
Vital, Anne
Bézard, Erwan
Dehay, Benjamin
author_sort Canron, Marie-Hélène
collection PubMed
description Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebus murinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebus murinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.
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spelling pubmed-35104642012-11-30 Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate Canron, Marie-Hélène Perret, Martine Vital, Anne Bézard, Erwan Dehay, Benjamin Sci Rep Article Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebus murinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebus murinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases. Nature Publishing Group 2012-11-30 /pmc/articles/PMC3510464/ /pubmed/23205271 http://dx.doi.org/10.1038/srep00910 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Canron, Marie-Hélène
Perret, Martine
Vital, Anne
Bézard, Erwan
Dehay, Benjamin
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
title Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
title_full Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
title_fullStr Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
title_full_unstemmed Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
title_short Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
title_sort age-dependent α-synuclein aggregation in the microcebus murinus lemur primate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510464/
https://www.ncbi.nlm.nih.gov/pubmed/23205271
http://dx.doi.org/10.1038/srep00910
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