Bacillithiol is an antioxidant thiol produced in Bacilli

Glutathione is a nearly ubiquitous low-molecular-weight thiol and antioxidant, although it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a novel and abundant thiol produced by Bacillus species, Staphylococcus aureus, and Deinococcus radiodu...

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Autores principales: Newton, Gerald L., Rawat, Mamta, La Clair, James J., Jothivasan, Vishnu Karthik, Budiarto, Tanya, Hamilton, Chris J., Claiborne, Al, Helmann, John D., Fahey, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510479/
https://www.ncbi.nlm.nih.gov/pubmed/19578333
http://dx.doi.org/10.1038/nchembio.189
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author Newton, Gerald L.
Rawat, Mamta
La Clair, James J.
Jothivasan, Vishnu Karthik
Budiarto, Tanya
Hamilton, Chris J.
Claiborne, Al
Helmann, John D.
Fahey, Robert C.
author_facet Newton, Gerald L.
Rawat, Mamta
La Clair, James J.
Jothivasan, Vishnu Karthik
Budiarto, Tanya
Hamilton, Chris J.
Claiborne, Al
Helmann, John D.
Fahey, Robert C.
author_sort Newton, Gerald L.
collection PubMed
description Glutathione is a nearly ubiquitous low-molecular-weight thiol and antioxidant, although it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a novel and abundant thiol produced by Bacillus species, Staphylococcus aureus, and Deinococcus radiodurans. Bacillithiol is the α-anomeric glycoside of l-cysteinyl-d-glucosamine with l-malic acid and likely functions as an antioxidant. Bacillithiol, like structurally similar mycothiol, may serve as a substitute for glutathione.
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spelling pubmed-35104792012-11-30 Bacillithiol is an antioxidant thiol produced in Bacilli Newton, Gerald L. Rawat, Mamta La Clair, James J. Jothivasan, Vishnu Karthik Budiarto, Tanya Hamilton, Chris J. Claiborne, Al Helmann, John D. Fahey, Robert C. Nat Chem Biol Article Glutathione is a nearly ubiquitous low-molecular-weight thiol and antioxidant, although it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a novel and abundant thiol produced by Bacillus species, Staphylococcus aureus, and Deinococcus radiodurans. Bacillithiol is the α-anomeric glycoside of l-cysteinyl-d-glucosamine with l-malic acid and likely functions as an antioxidant. Bacillithiol, like structurally similar mycothiol, may serve as a substitute for glutathione. 2009-07-05 2009-09 /pmc/articles/PMC3510479/ /pubmed/19578333 http://dx.doi.org/10.1038/nchembio.189 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Newton, Gerald L.
Rawat, Mamta
La Clair, James J.
Jothivasan, Vishnu Karthik
Budiarto, Tanya
Hamilton, Chris J.
Claiborne, Al
Helmann, John D.
Fahey, Robert C.
Bacillithiol is an antioxidant thiol produced in Bacilli
title Bacillithiol is an antioxidant thiol produced in Bacilli
title_full Bacillithiol is an antioxidant thiol produced in Bacilli
title_fullStr Bacillithiol is an antioxidant thiol produced in Bacilli
title_full_unstemmed Bacillithiol is an antioxidant thiol produced in Bacilli
title_short Bacillithiol is an antioxidant thiol produced in Bacilli
title_sort bacillithiol is an antioxidant thiol produced in bacilli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510479/
https://www.ncbi.nlm.nih.gov/pubmed/19578333
http://dx.doi.org/10.1038/nchembio.189
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