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The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

The CCR4–NOT complex plays a crucial role in post-transcriptional mRNA regulation in eukaryotic cells. It catalyzes the removal of mRNA poly(A) tails, thereby repressing translation and committing mRNAs to decay. The conserved core of the complex consists of a catalytic module comprising two deadeny...

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Detalles Bibliográficos
Autores principales:	Petit, Alain-Pierre, Wohlbold, Lara, Bawankar, Praveen, Huntzinger, Eric, Schmidt, Steffen, Izaurralde, Elisa, Weichenrieder, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510486/ https://www.ncbi.nlm.nih.gov/pubmed/22977175 http://dx.doi.org/10.1093/nar/gks883

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