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Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance

Unrepaired DNA damage may arrest ongoing replication forks, potentially resulting in fork collapse, increased mutagenesis and genomic instability. Replication through DNA lesions depends on mono- and polyubiquitylation of proliferating cell nuclear antigen (PCNA), which enable translesion synthesis...

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Detalles Bibliográficos
Autores principales:	Juhasz, Szilvia, Balogh, David, Hajdu, Ildiko, Burkovics, Peter, Villamil, Mark A., Zhuang, Zhihao, Haracska, Lajos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510514/ https://www.ncbi.nlm.nih.gov/pubmed/22987070 http://dx.doi.org/10.1093/nar/gks850

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