The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila

SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component...

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Autores principales: Gurskiy, Dmitriy, Orlova, Anastasija, Vorobyeva, Nadezhda, Nabirochkina, Elena, Krasnov, Alexey, Shidlovskii, Yulii, Georgieva, Sofia, Kopytova, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510517/
https://www.ncbi.nlm.nih.gov/pubmed/22989713
http://dx.doi.org/10.1093/nar/gks857
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author Gurskiy, Dmitriy
Orlova, Anastasija
Vorobyeva, Nadezhda
Nabirochkina, Elena
Krasnov, Alexey
Shidlovskii, Yulii
Georgieva, Sofia
Kopytova, Daria
author_facet Gurskiy, Dmitriy
Orlova, Anastasija
Vorobyeva, Nadezhda
Nabirochkina, Elena
Krasnov, Alexey
Shidlovskii, Yulii
Georgieva, Sofia
Kopytova, Daria
author_sort Gurskiy, Dmitriy
collection PubMed
description SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component of the cap-binding complex and is thereby recruited onto growing messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus. Thus, Sgf11 functions as a component of both SAGA DUBm and the mRNA biogenesis machinery.
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spelling pubmed-35105172012-11-30 The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila Gurskiy, Dmitriy Orlova, Anastasija Vorobyeva, Nadezhda Nabirochkina, Elena Krasnov, Alexey Shidlovskii, Yulii Georgieva, Sofia Kopytova, Daria Nucleic Acids Res Gene Regulation, Chromatin and Epigenetics SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component of the cap-binding complex and is thereby recruited onto growing messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus. Thus, Sgf11 functions as a component of both SAGA DUBm and the mRNA biogenesis machinery. Oxford University Press 2012-11 2012-09-18 /pmc/articles/PMC3510517/ /pubmed/22989713 http://dx.doi.org/10.1093/nar/gks857 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Gene Regulation, Chromatin and Epigenetics
Gurskiy, Dmitriy
Orlova, Anastasija
Vorobyeva, Nadezhda
Nabirochkina, Elena
Krasnov, Alexey
Shidlovskii, Yulii
Georgieva, Sofia
Kopytova, Daria
The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
title The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
title_full The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
title_fullStr The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
title_full_unstemmed The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
title_short The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
title_sort dubm subunit sgf11 is required for mrna export and interacts with cbp80 in drosophila
topic Gene Regulation, Chromatin and Epigenetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510517/
https://www.ncbi.nlm.nih.gov/pubmed/22989713
http://dx.doi.org/10.1093/nar/gks857
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