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Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo

Fibroblast growth factor 19 (FGF19) is a postprandial enterokine induced by the nuclear bile acid receptor, FXR, in ileum. FGF19 inhibits bile acid synthesis in liver through transcriptional repression of cholesterol 7α-hydroxylase (CYP7A1) via a mechanism involving the nuclear receptor SHP. Here, i...

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Detalles Bibliográficos
Autores principales:	Kir, Serkan, Zhang, Yuan, Gerard, Robert D., Kliewer, Steven A., Mangelsdorf, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510831/ https://www.ncbi.nlm.nih.gov/pubmed/23038264 http://dx.doi.org/10.1074/jbc.M112.421834

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