Cargando…
Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice
BACKGROUND: Like other citrus fruits, natsumikan (Citrus natsudaidai) contains several antioxidative nutrients which occur in higher concentrations in the peel than in the pulp. A high dose of acetaminophen (APAP) generates highly reactive intermediates and causes fatal liver injury. In this study,...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510878/ https://www.ncbi.nlm.nih.gov/pubmed/23225969 http://dx.doi.org/10.4103/0974-8490.102274 |
_version_ | 1782251505079812096 |
---|---|
author | Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Ueno, Koichi |
author_facet | Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Ueno, Koichi |
author_sort | Yamaura, Katsunori |
collection | PubMed |
description | BACKGROUND: Like other citrus fruits, natsumikan (Citrus natsudaidai) contains several antioxidative nutrients which occur in higher concentrations in the peel than in the pulp. A high dose of acetaminophen (APAP) generates highly reactive intermediates and causes fatal liver injury. In this study, we examined whether an extract from immature natsumikan peel prevents lethal hepatotoxicity induced by a lethal dose of APAP in mice. MATERIALS AND METHODS: Male ICR mice were treated orally with natsumikan extract (300 and 1,000 mg/kg) 2, 26, and 50 h before single oral APAP (300 mg/kg) administration. Mice were fasted for 18 h before APAP treatment, but given tap water ad libitum. Survival was assessed for 24 h after APAP treatment. RESULTS: Following administration of 300 mg/kg APAP, all mice died within 6 h. However, pretreatment with natsumikan extract (300 and 1,000 mg/kg) or silymarin (300 and 1,000 mg/kg) increased the survival rate to 16.7%, 33.3%, 16.7%, and 50%, respectively, at 24 h. CONCLUSION: The results suggest that natsumikan has a protective effect on APAP-induced lethal hepatotoxicity. |
format | Online Article Text |
id | pubmed-3510878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35108782012-12-05 Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Ueno, Koichi Pharmacognosy Res Short Communication BACKGROUND: Like other citrus fruits, natsumikan (Citrus natsudaidai) contains several antioxidative nutrients which occur in higher concentrations in the peel than in the pulp. A high dose of acetaminophen (APAP) generates highly reactive intermediates and causes fatal liver injury. In this study, we examined whether an extract from immature natsumikan peel prevents lethal hepatotoxicity induced by a lethal dose of APAP in mice. MATERIALS AND METHODS: Male ICR mice were treated orally with natsumikan extract (300 and 1,000 mg/kg) 2, 26, and 50 h before single oral APAP (300 mg/kg) administration. Mice were fasted for 18 h before APAP treatment, but given tap water ad libitum. Survival was assessed for 24 h after APAP treatment. RESULTS: Following administration of 300 mg/kg APAP, all mice died within 6 h. However, pretreatment with natsumikan extract (300 and 1,000 mg/kg) or silymarin (300 and 1,000 mg/kg) increased the survival rate to 16.7%, 33.3%, 16.7%, and 50%, respectively, at 24 h. CONCLUSION: The results suggest that natsumikan has a protective effect on APAP-induced lethal hepatotoxicity. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3510878/ /pubmed/23225969 http://dx.doi.org/10.4103/0974-8490.102274 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Yamaura, Katsunori Nakayama, Noriyuki Shimada, Maki Ueno, Koichi Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
title | Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
title_full | Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
title_fullStr | Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
title_full_unstemmed | Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
title_short | Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
title_sort | protective effects of natsumikan (citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510878/ https://www.ncbi.nlm.nih.gov/pubmed/23225969 http://dx.doi.org/10.4103/0974-8490.102274 |
work_keys_str_mv | AT yamaurakatsunori protectiveeffectsofnatsumikancitrusnatsudaidaiextractonacetaminopheninducedlethalhepatotoxicityinmice AT nakayamanoriyuki protectiveeffectsofnatsumikancitrusnatsudaidaiextractonacetaminopheninducedlethalhepatotoxicityinmice AT shimadamaki protectiveeffectsofnatsumikancitrusnatsudaidaiextractonacetaminopheninducedlethalhepatotoxicityinmice AT uenokoichi protectiveeffectsofnatsumikancitrusnatsudaidaiextractonacetaminopheninducedlethalhepatotoxicityinmice |