Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfur- or nitrogen-containing heterocycles ha...

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Detalles Bibliográficos
Autores principales: Martin, Anthony R, Chartoire, Anthony, Slawin, Alexandra M Z, Nolan, Steven P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510996/
https://www.ncbi.nlm.nih.gov/pubmed/23209496
http://dx.doi.org/10.3762/bjoc.8.187
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author Martin, Anthony R
Chartoire, Anthony
Slawin, Alexandra M Z
Nolan, Steven P
author_facet Martin, Anthony R
Chartoire, Anthony
Slawin, Alexandra M Z
Nolan, Steven P
author_sort Martin, Anthony R
collection PubMed
description The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfur- or nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium.
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spelling pubmed-35109962012-12-03 Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles Martin, Anthony R Chartoire, Anthony Slawin, Alexandra M Z Nolan, Steven P Beilstein J Org Chem Full Research Paper The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfur- or nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium. Beilstein-Institut 2012-09-27 /pmc/articles/PMC3510996/ /pubmed/23209496 http://dx.doi.org/10.3762/bjoc.8.187 Text en Copyright © 2012, Martin et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Martin, Anthony R
Chartoire, Anthony
Slawin, Alexandra M Z
Nolan, Steven P
Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
title Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
title_full Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
title_fullStr Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
title_full_unstemmed Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
title_short Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
title_sort extending the utility of [pd(nhc)(cinnamyl)cl] precatalysts: direct arylation of heterocycles
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510996/
https://www.ncbi.nlm.nih.gov/pubmed/23209496
http://dx.doi.org/10.3762/bjoc.8.187
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