trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family

A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4-iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT(2) family of receptors; and the more potent stereoisomer o...

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Detalles Bibliográficos
Autores principales: Pigott, Adam, Frescas, Stewart, McCorvy, John D, Huang, Xi-Ping, Roth, Bryan L, Nichols, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511003/
https://www.ncbi.nlm.nih.gov/pubmed/23209503
http://dx.doi.org/10.3762/bjoc.8.194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511003/
https://www.ncbi.nlm.nih.gov/pubmed/23209503
http://dx.doi.org/10.3762/bjoc.8.194

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