Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

A new selaginellin named selaginellin O (1), along with three other known selaginellins (2–4) were isolated from Selaginella tamariscina (Beauv.) Spring. On the basis of spectroscopic analysis, the structure of selaginellin O was demonstrated to be 4-[(4’-hydroxy-4-formyl-3-((4-hydroxyphenyl)ethynyl...

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Detalles Bibliográficos
Autores principales: Yang, Chao, Shao, Yutian, Li, Kang, Xia, Wujiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511026/
https://www.ncbi.nlm.nih.gov/pubmed/23209526
http://dx.doi.org/10.3762/bjoc.8.217
Descripción
Sumario:A new selaginellin named selaginellin O (1), along with three other known selaginellins (2–4) were isolated from Selaginella tamariscina (Beauv.) Spring. On the basis of spectroscopic analysis, the structure of selaginellin O was demonstrated to be 4-[(4’-hydroxy-4-formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity.

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