Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis

Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the c...

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Detalles Bibliográficos
Autores principales: Yin, Jian, Eller, Steffen, Collot, Mayeul, Seeberger, Peter H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511041/
https://www.ncbi.nlm.nih.gov/pubmed/23209541
http://dx.doi.org/10.3762/bjoc.8.232
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author Yin, Jian
Eller, Steffen
Collot, Mayeul
Seeberger, Peter H
author_facet Yin, Jian
Eller, Steffen
Collot, Mayeul
Seeberger, Peter H
author_sort Yin, Jian
collection PubMed
description Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis.
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spelling pubmed-35110412012-12-03 Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis Yin, Jian Eller, Steffen Collot, Mayeul Seeberger, Peter H Beilstein J Org Chem Letter Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis. Beilstein-Institut 2012-11-26 /pmc/articles/PMC3511041/ /pubmed/23209541 http://dx.doi.org/10.3762/bjoc.8.232 Text en Copyright © 2012, Yin et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Yin, Jian
Eller, Steffen
Collot, Mayeul
Seeberger, Peter H
Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
title Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
title_full Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
title_fullStr Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
title_full_unstemmed Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
title_short Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
title_sort acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511041/
https://www.ncbi.nlm.nih.gov/pubmed/23209541
http://dx.doi.org/10.3762/bjoc.8.232
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