Cargando…

Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies

The low transfection efficiency of chitosan is one of its drawbacks as a gene delivery carrier. Low molecular weight chitosan may help to form small-sized polymer-DNA or small interfering RNA (siRNA) complexes. Folate conjugation may improve gene transfection efficiency because of the promoted uptak...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandes, Julio C, Qiu, Xingping, Winnik, Francoise M, Benderdour, Mohamed, Zhang, Xiaoling, Dai, Kerong, Shi, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511191/ https://www.ncbi.nlm.nih.gov/pubmed/23209368 http://dx.doi.org/10.2147/IJN.S35567

Ejemplares similares

Hydrodynamic Delivery of Chitosan-Folate-DNA Nanoparticles in Rats with Adjuvant-Induced Arthritis
por: Shi, Qin, et al.
Publicado: (2011)

Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro
por: Fernandes, Julio C, et al.
Publicado: (2013)

Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles In Vitro
por: Jreyssaty, Christian, et al.
Publicado: (2012)

In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice
por: Shi, Qin, et al.
Publicado: (2018)

Chitosan-Based Glycolipid Conjugated siRNA Delivery System for Improving Radiosensitivity of Laryngocarcinoma
por: Miao, Jing, et al.
Publicado: (2021)

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing
por: Dohmen, Christian, et al.
Publicado: (2012)

Chaperonin–Dendrimer Conjugates for siRNA Delivery
por: Nussbaumer, Martin G., et al.
Publicado: (2016)

Chitosan and Its Structural Modifications for siRNA Delivery
por: Al-Absi, Mona Y., et al.
Publicado: (2023)

Molecular Umbrella Conjugate for the Ocular Delivery of siRNA
por: Janout, Vaclav, et al.
Publicado: (2014)

Gold Nanoparticles Conjugated with Dendrigraft Poly-L-lysine and Folate-Targeted Poly(ethylene glycol) for siRNA Delivery to Prostate cancer
por: Minassian, Georges, et al.
Publicado: (2023)

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates
por: Cuellar, Trinna L., et al.
Publicado: (2015)

Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model
por: Zhu, Qiqi, et al.
Publicado: (2013)

Spreading of Cell Aggregates on Zwitterion-Modified Chitosan Films
por: Qi, Baowen, et al.
Publicado: (2018)

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery
por: Saeed, Ramzi Mukred, et al.
Publicado: (2021)

In Vitro Cellular Uptake and Transfection of Oligoarginine-Conjugated Glycol Chitosan/siRNA Nanoparticles
por: Jeong, Eun-Ju, et al.
Publicado: (2021)

Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery
por: Li, Hongmei, et al.
Publicado: (2014)

High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA
por: Ye, Junxiao, et al.
Publicado: (2017)

Difatty Acyl-Conjugated Linear and Cyclic Peptides for siRNA Delivery
por: Do, Hung, et al.
Publicado: (2017)

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition
por: Berezhnoy, Alexey, et al.
Publicado: (2012)

Two Birds with One Stone: A Novel Dithiomaleimide-Based GalNAc-siRNA Conjugate Enabling Good siRNA Delivery and Traceability
por: Kong, Sudong, et al.
Publicado: (2023)

Development and characterization of chitosan-PEG-TAT nanoparticles for the intracellular delivery of siRNA
por: Malhotra, Meenakshi, et al.
Publicado: (2013)

Chitosan Oleate Coated PLGA Nanoparticles as siRNA Drug Delivery System
por: Miele, Dalila, et al.
Publicado: (2021)

Improved method for synthesis of low molecular weight protamine–siRNA conjugate
por: Yu, Zhili, et al.
Publicado: (2018)

Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles
por: Ballarín-González, Borja, et al.
Publicado: (2013)

Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts
por: Silva, Asitha T, et al.
Publicado: (2010)

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
por: Biscans, Annabelle, et al.
Publicado: (2019)

Development of Chitosan Nanoparticles as a Stable Drug Delivery System for Protein/siRNA
por: Katas, Haliza, et al.
Publicado: (2013)

Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles
por: Malhotra, Meenakshi, et al.
Publicado: (2013)

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
por: Capel, Victoria, et al.
Publicado: (2018)

Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives
por: Serrano-Sevilla, Inés, et al.
Publicado: (2019)

Polymerized Selenium Nanoparticles for Folate-Receptor-Targeted Delivery of Anti-Luc-siRNA: Potential for Gene Silencing
por: Maiyo, Fiona, et al.
Publicado: (2020)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

Dendrimers for siRNA Delivery
por: Biswas, Swati, et al.
Publicado: (2013)

Optimizing Mannose “Click” Conjugation to Polymeric Nanoparticles for Targeted siRNA Delivery to Human and Murine Macrophages
por: Glass, Evan B., et al.
Publicado: (2019)

Application of quantum dots as vectors in targeted survivin gene siRNA delivery
por: Zhao, Jianjiang, et al.
Publicado: (2013)

Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers
por: Gauthier, Florian, et al.
Publicado: (2020)

Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs
por: Zhang, Huifang M., et al.
Publicado: (2009)

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
por: Hassler, Matthew R, et al.
Publicado: (2018)

Enhanced Intercellular Delivery of cRGD–siRNA Conjugates by an Additional Oligospermine Modification
por: Nakamoto, Kosuke, et al.
Publicado: (2018)

Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates
por: Sharma, Meenakshi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cv3i58on7e2dbfmnlf6pg7psbi