Cargando…

Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage

BACKGROUND: Lung allografts contain large amounts of iron (Fe), which inside lung macrophages may promote oxidative lysosomal membrane permeabilization (LMP), cell death and inflammation. The macrolide antibiotic azithromycin (AZM) accumulates 1000-fold inside the acidic lysosomes and may interfere...

Descripción completa

Detalles Bibliográficos
Autores principales:	Persson, H L, Vainikka, Linda K, Sege, Maria, Wennerström, Urban, Dam-Larsen, Sören, Persson, Jenny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511206/ https://www.ncbi.nlm.nih.gov/pubmed/23006592 http://dx.doi.org/10.1186/1465-9921-13-83

Ejemplares similares

Oxidant-induced autophagy and ferritin degradation contribute to epithelial–mesenchymal transition through lysosomal iron
por: Sioutas, Apostolos, et al.
Publicado: (2017)

Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs
por: Persson, Hans L, et al.
Publicado: (2013)

Human Lung Macrophages Challenged to Oxidants ex vivo: Lysosomal Membrane Sensitization is Associated with Inflammation and Chronic Airflow Limitation
por: Persson, Hans Lennart, et al.
Publicado: (2020)

Real-Time Monitoring of Lysosomal Membrane Permeabilization Using Acridine Orange
por: Eriksson, Ida, et al.
Publicado: (2023)

Sunbathing: What've lysosomes got to do with it?
por: Wäster, Petra, et al.
Publicado: (2014)

Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin
por: Derendorf, Hartmut
Publicado: (2020)

Leaky Gut, Leaky Brain?
por: Obrenovich, Mark E. M.
Publicado: (2018)

Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
por: Toriyama, Kazutoshi, et al.
Publicado: (2021)

A Leaky Blood–Brain Barrier to Fibrinogen Contributes to Oxidative Damage in Alzheimer’s Disease
por: McLarnon, James G.
Publicado: (2021)

Leaky barriers: leaky enough for fish to pass?
por: Müller, Stephanie, et al.
Publicado: (2021)

Macrophage inflammatory state influences susceptibility to lysosomal damage
por: Wong, Amanda O., et al.
Publicado: (2021)

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
por: Bussi, Claudio, et al.
Publicado: (2022)

Observation of directional leaky polaritons at anisotropic crystal interfaces
por: Ni, Xiang, et al.
Publicado: (2023)

Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage
por: Gai, Chengcheng, et al.
Publicado: (2023)

Total Gastrointestinal Flora Transplantation in the Treatment of Leaky Gut Syndrome and Flora Loss
por: Kanlioz, Murat, et al.
Publicado: (2022)

Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia
por: Li, Liang, et al.
Publicado: (2015)

Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages
por: Persson, Jenny, et al.
Publicado: (2006)

How vessels become leaky
por: Wells, William A.
Publicado: (2005)

‘Leaky gut’ in hematological malignancies()
por: Costa-Lima, Carolina, et al.
Publicado: (2014)

Diseases associated with leaky hemichannels
por: Retamal, Mauricio A., et al.
Publicado: (2015)

Paradoxes in leaky microbial trade
por: Kallus, Yoav, et al.
Publicado: (2017)

Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation
por: Menzel, Mandy, et al.
Publicado: (2017)

Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress
por: Cho, Young-Eun, et al.
Publicado: (2018)

Leaky feeders and subsurface radio communication
por: Delogne, Paul
Publicado: (1982)

The Role of Leaky Gut in Functional Dyspepsia
por: Wauters, Lucas, et al.
Publicado: (2022)

Leaky and waveguide modes in biperiodic holograms
por: Keshmiri, Hamid, et al.
Publicado: (2021)

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells
por: Persson, Jenny, et al.
Publicado: (2008)

Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture
por: Rajapakse, Dinusha, et al.
Publicado: (2017)

Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy
por: Ben-Kraiem, Adel, et al.
Publicado: (2021)

Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons
por: Vasudevan, Shashank, et al.
Publicado: (2019)

Poria cocos polysaccharide prevents alcohol-induced hepatic injury and inflammation by repressing oxidative stress and gut leakiness
por: Jiang, Yue-hang, et al.
Publicado: (2022)

Lysosomal oxidation of LDL alters lysosomal pH, induces senescence, and increases secretion of pro-inflammatory cytokines in human macrophages
por: Ahmad, Feroz, et al.
Publicado: (2019)

Liver transplantation for azithromycin-induced severe liver injury
por: Park, Hyun Joon, et al.
Publicado: (2020)

Leaky resistance and the conditions for the existence of lytic bacteriophage
por: Chaudhry, Waqas N., et al.
Publicado: (2018)

Retinoic Acid, Leaky Gut, and Autoimmune Diseases
por: Abdelhamid, Leila, et al.
Publicado: (2018)

Leaky gut biomarkers in depression and suicidal behavior
por: Ohlsson, L., et al.
Publicado: (2018)

Hemolytic Anemia: Sneaky Cause, Leaky Valve
por: Rai, Maitreyee, et al.
Publicado: (2020)

Leaky Gum: The Revisited Origin of Systemic Diseases
por: Park, Do-Young, et al.
Publicado: (2022)

Gut Microbiota, Leaky Gut, and Autoimmune Diseases
por: Christovich, Anna, et al.
Publicado: (2022)

Anionic nanoplastic exposure induces endothelial leakiness
por: Wei, Wei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ha35irjasupvqr9p1h6leddv9m