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Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex

A fundamental issue in cognitive neuroscience is the existence of two major, sub-lexical and lexical, reading processes and their possible segregation in the left posterior perisylvian cortex. Using cortical electrostimulation mapping, we identified the cortical areas involved on reading either orth...

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Autores principales: Roux, Franck-Emmanuel, Durand, Jean-Baptiste, Jucla, Mélanie, Réhault, Emilie, Reddy, Marion, Démonet, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511309/
https://www.ncbi.nlm.nih.gov/pubmed/23226349
http://dx.doi.org/10.1371/journal.pone.0050665
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author Roux, Franck-Emmanuel
Durand, Jean-Baptiste
Jucla, Mélanie
Réhault, Emilie
Reddy, Marion
Démonet, Jean-François
author_facet Roux, Franck-Emmanuel
Durand, Jean-Baptiste
Jucla, Mélanie
Réhault, Emilie
Reddy, Marion
Démonet, Jean-François
author_sort Roux, Franck-Emmanuel
collection PubMed
description A fundamental issue in cognitive neuroscience is the existence of two major, sub-lexical and lexical, reading processes and their possible segregation in the left posterior perisylvian cortex. Using cortical electrostimulation mapping, we identified the cortical areas involved on reading either orthographically irregular words (lexical, “direct” process) or pronounceable pseudowords (sublexical, “indirect” process) in 14 right-handed neurosurgical patients while video-recording behavioral effects. Intraoperative neuronavigation system and Montreal Neurological Institute (MNI) stereotactic coordinates were used to identify the localization of stimulation sites. Fifty-one reading interference areas were found that affected either words (14 areas), or pseudo-words (11 areas), or both (26 areas). Forty-one (80%) corresponded to the impairment of the phonological level of reading processes. Reading processes involved discrete, highly localized perisylvian cortical areas with individual variability. MNI coordinates throughout the group exhibited a clear segregation according to the tested reading route; specific pseudo-word reading interferences were concentrated in a restricted inferior and anterior subpart of the left supramarginal gyrus (barycentre x = −68.1; y = −25.9; z = 30.2; Brodmann’s area 40) while specific word reading areas were located almost exclusively alongside the left superior temporal gyrus. Although half of the reading interferences found were nonspecific, the finding of specific lexical or sublexical interferences is new evidence that lexical and sublexical processes of reading could be partially supported by distinct cortical sub-regions despite their anatomical proximity. These data are in line with many brain activation studies that showed that left superior temporal and inferior parietal regions had a crucial role respectively in word and pseudoword reading and were core regions for dyslexia.
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spelling pubmed-35113092012-12-05 Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex Roux, Franck-Emmanuel Durand, Jean-Baptiste Jucla, Mélanie Réhault, Emilie Reddy, Marion Démonet, Jean-François PLoS One Research Article A fundamental issue in cognitive neuroscience is the existence of two major, sub-lexical and lexical, reading processes and their possible segregation in the left posterior perisylvian cortex. Using cortical electrostimulation mapping, we identified the cortical areas involved on reading either orthographically irregular words (lexical, “direct” process) or pronounceable pseudowords (sublexical, “indirect” process) in 14 right-handed neurosurgical patients while video-recording behavioral effects. Intraoperative neuronavigation system and Montreal Neurological Institute (MNI) stereotactic coordinates were used to identify the localization of stimulation sites. Fifty-one reading interference areas were found that affected either words (14 areas), or pseudo-words (11 areas), or both (26 areas). Forty-one (80%) corresponded to the impairment of the phonological level of reading processes. Reading processes involved discrete, highly localized perisylvian cortical areas with individual variability. MNI coordinates throughout the group exhibited a clear segregation according to the tested reading route; specific pseudo-word reading interferences were concentrated in a restricted inferior and anterior subpart of the left supramarginal gyrus (barycentre x = −68.1; y = −25.9; z = 30.2; Brodmann’s area 40) while specific word reading areas were located almost exclusively alongside the left superior temporal gyrus. Although half of the reading interferences found were nonspecific, the finding of specific lexical or sublexical interferences is new evidence that lexical and sublexical processes of reading could be partially supported by distinct cortical sub-regions despite their anatomical proximity. These data are in line with many brain activation studies that showed that left superior temporal and inferior parietal regions had a crucial role respectively in word and pseudoword reading and were core regions for dyslexia. Public Library of Science 2012-11-30 /pmc/articles/PMC3511309/ /pubmed/23226349 http://dx.doi.org/10.1371/journal.pone.0050665 Text en © 2012 Roux et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Roux, Franck-Emmanuel
Durand, Jean-Baptiste
Jucla, Mélanie
Réhault, Emilie
Reddy, Marion
Démonet, Jean-François
Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex
title Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex
title_full Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex
title_fullStr Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex
title_full_unstemmed Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex
title_short Segregation of Lexical and Sub-Lexical Reading Processes in the Left Perisylvian Cortex
title_sort segregation of lexical and sub-lexical reading processes in the left perisylvian cortex
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511309/
https://www.ncbi.nlm.nih.gov/pubmed/23226349
http://dx.doi.org/10.1371/journal.pone.0050665
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