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FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx

BACKGROUND: Fibroblast growth factor receptor 4 (FGFR4) is a member of a receptor tyrosine kinase family of enzymes involved in cell cycle control and proliferation. A common single nucleotide polymorphism (SNP) Gly388Arg variant has been associated with increased tumor cell motility and progression...

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Autores principales: Dutra, Roberta Lelis, de Carvalho, Marcos Brasilino, dos Santos, Marcelo, Mercante, Ana Maria da Cunha, Gazito, Diana, de Cicco, Rafael, Group, GENCAPO, Tajara, Eloiza Helena, Louro, Iúri Drumond, da Silva, Adriana Madeira Álvares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511351/
https://www.ncbi.nlm.nih.gov/pubmed/23226373
http://dx.doi.org/10.1371/journal.pone.0050747
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author Dutra, Roberta Lelis
de Carvalho, Marcos Brasilino
dos Santos, Marcelo
Mercante, Ana Maria da Cunha
Gazito, Diana
de Cicco, Rafael
Group, GENCAPO
Tajara, Eloiza Helena
Louro, Iúri Drumond
da Silva, Adriana Madeira Álvares
author_facet Dutra, Roberta Lelis
de Carvalho, Marcos Brasilino
dos Santos, Marcelo
Mercante, Ana Maria da Cunha
Gazito, Diana
de Cicco, Rafael
Group, GENCAPO
Tajara, Eloiza Helena
Louro, Iúri Drumond
da Silva, Adriana Madeira Álvares
author_sort Dutra, Roberta Lelis
collection PubMed
description BACKGROUND: Fibroblast growth factor receptor 4 (FGFR4) is a member of a receptor tyrosine kinase family of enzymes involved in cell cycle control and proliferation. A common single nucleotide polymorphism (SNP) Gly388Arg variant has been associated with increased tumor cell motility and progression of breast cancer, head and neck cancer and soft tissue sarcomas. The present study evaluated the prognostic significance of FGFR4 in oral and oropharynx carcinomas, finding an association of FGFR4 expression and Gly388Arg genotype with tumor onset and prognosis. PATIENTS AND METHODS: DNA from peripheral blood of 122 patients with oral and oropharyngeal squamous cell carcinomas was used to determine FGFR4 genotype by PCR-RFLP. Protein expression was assessed by immunohistochemistry (IHC) on paraffin-embedded tissue microarrays. RESULTS: Presence of allele Arg388 was associated with lymphatic embolization and with disease related premature death. In addition, FGFR4 low expression was related with lymph node positivity and premature relapse of disease, as well as disease related death. CONCLUSION: Our results propose FGFR4 profile, measured by the Gly388Arg genotype and expression, as a novel marker of prognosis in squamous cell carcinoma of the mouth and oropharynx.
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spelling pubmed-35113512012-12-05 FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx Dutra, Roberta Lelis de Carvalho, Marcos Brasilino dos Santos, Marcelo Mercante, Ana Maria da Cunha Gazito, Diana de Cicco, Rafael Group, GENCAPO Tajara, Eloiza Helena Louro, Iúri Drumond da Silva, Adriana Madeira Álvares PLoS One Research Article BACKGROUND: Fibroblast growth factor receptor 4 (FGFR4) is a member of a receptor tyrosine kinase family of enzymes involved in cell cycle control and proliferation. A common single nucleotide polymorphism (SNP) Gly388Arg variant has been associated with increased tumor cell motility and progression of breast cancer, head and neck cancer and soft tissue sarcomas. The present study evaluated the prognostic significance of FGFR4 in oral and oropharynx carcinomas, finding an association of FGFR4 expression and Gly388Arg genotype with tumor onset and prognosis. PATIENTS AND METHODS: DNA from peripheral blood of 122 patients with oral and oropharyngeal squamous cell carcinomas was used to determine FGFR4 genotype by PCR-RFLP. Protein expression was assessed by immunohistochemistry (IHC) on paraffin-embedded tissue microarrays. RESULTS: Presence of allele Arg388 was associated with lymphatic embolization and with disease related premature death. In addition, FGFR4 low expression was related with lymph node positivity and premature relapse of disease, as well as disease related death. CONCLUSION: Our results propose FGFR4 profile, measured by the Gly388Arg genotype and expression, as a novel marker of prognosis in squamous cell carcinoma of the mouth and oropharynx. Public Library of Science 2012-11-30 /pmc/articles/PMC3511351/ /pubmed/23226373 http://dx.doi.org/10.1371/journal.pone.0050747 Text en © 2012 Dutra et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dutra, Roberta Lelis
de Carvalho, Marcos Brasilino
dos Santos, Marcelo
Mercante, Ana Maria da Cunha
Gazito, Diana
de Cicco, Rafael
Group, GENCAPO
Tajara, Eloiza Helena
Louro, Iúri Drumond
da Silva, Adriana Madeira Álvares
FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx
title FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx
title_full FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx
title_fullStr FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx
title_full_unstemmed FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx
title_short FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx
title_sort fgfr4 profile as a prognostic marker in squamous cell carcinoma of the mouth and oropharynx
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511351/
https://www.ncbi.nlm.nih.gov/pubmed/23226373
http://dx.doi.org/10.1371/journal.pone.0050747
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