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An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging

AIM: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). MATERIALS AND METHODS: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Us...

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Autores principales: Wang, Dan, Li, Wen-Bin, Wei, Xiao-Er, Li, Yue-Hua, Dai, Yong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511361/
https://www.ncbi.nlm.nih.gov/pubmed/23226360
http://dx.doi.org/10.1371/journal.pone.0050706
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author Wang, Dan
Li, Wen-Bin
Wei, Xiao-Er
Li, Yue-Hua
Dai, Yong-Ming
author_facet Wang, Dan
Li, Wen-Bin
Wei, Xiao-Er
Li, Yue-Hua
Dai, Yong-Ming
author_sort Wang, Dan
collection PubMed
description AIM: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). MATERIALS AND METHODS: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Using phase images to quantify iron deposition in the head of the caudate nucleus and the lenticular nucleus, the angle radian value was calculated and compared between groups. ANOVA/Pearson correlation coefficient linear regression analysis and polynomial fitting were performed to analyze the relationship between iron deposition in the head of the caudate nucleus and lenticular nucleus with age. RESULTS: Iron deposition in the lenticular nucleus increased in individuals aged up to 40 years, but did not change in those aged over 40 years once a peak had been reached. In the head of the caudate nucleus, iron deposition peaked at 60 years (p<0.05). The correlation coefficients for iron deposition in the L-head of the caudate nucleus, R-head of the caudate nucleus, L-lenticular nucleus and R-lenticular nucleus with age were 0.67691, 0.48585, 0.5228 and 0.5228 (p<0.001, respectively). Linear regression analyses showed a significant correlation between iron deposition levels in with age groups. CONCLUSIONS: Iron deposition in the lenticular nucleus was found to increase with age, reaching a plateau at 40 years. Iron deposition in the head of the caudate nucleus also increased with age, reaching a plateau at 60 years.
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spelling pubmed-35113612012-12-05 An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging Wang, Dan Li, Wen-Bin Wei, Xiao-Er Li, Yue-Hua Dai, Yong-Ming PLoS One Research Article AIM: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). MATERIALS AND METHODS: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Using phase images to quantify iron deposition in the head of the caudate nucleus and the lenticular nucleus, the angle radian value was calculated and compared between groups. ANOVA/Pearson correlation coefficient linear regression analysis and polynomial fitting were performed to analyze the relationship between iron deposition in the head of the caudate nucleus and lenticular nucleus with age. RESULTS: Iron deposition in the lenticular nucleus increased in individuals aged up to 40 years, but did not change in those aged over 40 years once a peak had been reached. In the head of the caudate nucleus, iron deposition peaked at 60 years (p<0.05). The correlation coefficients for iron deposition in the L-head of the caudate nucleus, R-head of the caudate nucleus, L-lenticular nucleus and R-lenticular nucleus with age were 0.67691, 0.48585, 0.5228 and 0.5228 (p<0.001, respectively). Linear regression analyses showed a significant correlation between iron deposition levels in with age groups. CONCLUSIONS: Iron deposition in the lenticular nucleus was found to increase with age, reaching a plateau at 40 years. Iron deposition in the head of the caudate nucleus also increased with age, reaching a plateau at 60 years. Public Library of Science 2012-11-30 /pmc/articles/PMC3511361/ /pubmed/23226360 http://dx.doi.org/10.1371/journal.pone.0050706 Text en © 2012 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Dan
Li, Wen-Bin
Wei, Xiao-Er
Li, Yue-Hua
Dai, Yong-Ming
An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
title An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
title_full An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
title_fullStr An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
title_full_unstemmed An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
title_short An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
title_sort investigation of age-related iron deposition using susceptibility weighted imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511361/
https://www.ncbi.nlm.nih.gov/pubmed/23226360
http://dx.doi.org/10.1371/journal.pone.0050706
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