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An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging
AIM: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). MATERIALS AND METHODS: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Us...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511361/ https://www.ncbi.nlm.nih.gov/pubmed/23226360 http://dx.doi.org/10.1371/journal.pone.0050706 |
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author | Wang, Dan Li, Wen-Bin Wei, Xiao-Er Li, Yue-Hua Dai, Yong-Ming |
author_facet | Wang, Dan Li, Wen-Bin Wei, Xiao-Er Li, Yue-Hua Dai, Yong-Ming |
author_sort | Wang, Dan |
collection | PubMed |
description | AIM: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). MATERIALS AND METHODS: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Using phase images to quantify iron deposition in the head of the caudate nucleus and the lenticular nucleus, the angle radian value was calculated and compared between groups. ANOVA/Pearson correlation coefficient linear regression analysis and polynomial fitting were performed to analyze the relationship between iron deposition in the head of the caudate nucleus and lenticular nucleus with age. RESULTS: Iron deposition in the lenticular nucleus increased in individuals aged up to 40 years, but did not change in those aged over 40 years once a peak had been reached. In the head of the caudate nucleus, iron deposition peaked at 60 years (p<0.05). The correlation coefficients for iron deposition in the L-head of the caudate nucleus, R-head of the caudate nucleus, L-lenticular nucleus and R-lenticular nucleus with age were 0.67691, 0.48585, 0.5228 and 0.5228 (p<0.001, respectively). Linear regression analyses showed a significant correlation between iron deposition levels in with age groups. CONCLUSIONS: Iron deposition in the lenticular nucleus was found to increase with age, reaching a plateau at 40 years. Iron deposition in the head of the caudate nucleus also increased with age, reaching a plateau at 60 years. |
format | Online Article Text |
id | pubmed-3511361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35113612012-12-05 An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging Wang, Dan Li, Wen-Bin Wei, Xiao-Er Li, Yue-Hua Dai, Yong-Ming PLoS One Research Article AIM: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). MATERIALS AND METHODS: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Using phase images to quantify iron deposition in the head of the caudate nucleus and the lenticular nucleus, the angle radian value was calculated and compared between groups. ANOVA/Pearson correlation coefficient linear regression analysis and polynomial fitting were performed to analyze the relationship between iron deposition in the head of the caudate nucleus and lenticular nucleus with age. RESULTS: Iron deposition in the lenticular nucleus increased in individuals aged up to 40 years, but did not change in those aged over 40 years once a peak had been reached. In the head of the caudate nucleus, iron deposition peaked at 60 years (p<0.05). The correlation coefficients for iron deposition in the L-head of the caudate nucleus, R-head of the caudate nucleus, L-lenticular nucleus and R-lenticular nucleus with age were 0.67691, 0.48585, 0.5228 and 0.5228 (p<0.001, respectively). Linear regression analyses showed a significant correlation between iron deposition levels in with age groups. CONCLUSIONS: Iron deposition in the lenticular nucleus was found to increase with age, reaching a plateau at 40 years. Iron deposition in the head of the caudate nucleus also increased with age, reaching a plateau at 60 years. Public Library of Science 2012-11-30 /pmc/articles/PMC3511361/ /pubmed/23226360 http://dx.doi.org/10.1371/journal.pone.0050706 Text en © 2012 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wang, Dan Li, Wen-Bin Wei, Xiao-Er Li, Yue-Hua Dai, Yong-Ming An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging |
title | An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging |
title_full | An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging |
title_fullStr | An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging |
title_full_unstemmed | An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging |
title_short | An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging |
title_sort | investigation of age-related iron deposition using susceptibility weighted imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511361/ https://www.ncbi.nlm.nih.gov/pubmed/23226360 http://dx.doi.org/10.1371/journal.pone.0050706 |
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