Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism

The polyglutamine (polyQ) diseases such as Huntington’s disease (HD), are neurodegenerative diseases caused by proteins with an expanded polyQ stretch, which misfold and aggregate, and eventually accumulate as inclusion bodies within neurons. Molecules that inhibit polyQ protein misfolding/aggregati...

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Detalles Bibliográficos
Autores principales: Popiel, H. Akiko, Takeuchi, Toshihide, Fujita, Hiromi, Yamamoto, Kazuhiro, Ito, Chiyomi, Yamane, Hiroshi, Muramatsu, Shin-ichi, Toda, Tatsushi, Wada, Keiji, Nagai, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511362/
https://www.ncbi.nlm.nih.gov/pubmed/23226463
http://dx.doi.org/10.1371/journal.pone.0051069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511362/
https://www.ncbi.nlm.nih.gov/pubmed/23226463
http://dx.doi.org/10.1371/journal.pone.0051069

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