Cargando…

Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism

The polyglutamine (polyQ) diseases such as Huntington’s disease (HD), are neurodegenerative diseases caused by proteins with an expanded polyQ stretch, which misfold and aggregate, and eventually accumulate as inclusion bodies within neurons. Molecules that inhibit polyQ protein misfolding/aggregati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Popiel, H. Akiko, Takeuchi, Toshihide, Fujita, Hiromi, Yamamoto, Kazuhiro, Ito, Chiyomi, Yamane, Hiroshi, Muramatsu, Shin-ichi, Toda, Tatsushi, Wada, Keiji, Nagai, Yoshitaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511362/ https://www.ncbi.nlm.nih.gov/pubmed/23226463 http://dx.doi.org/10.1371/journal.pone.0051069

Ejemplares similares

The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases
por: Popiel, H. Akiko, et al.
Publicado: (2011)

Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases
por: Takeuchi, Toshihide, et al.
Publicado: (2017)

Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms
por: Tomioka, Ikuo, et al.
Publicado: (2017)

Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain
por: Fukuoka, Masashi, et al.
Publicado: (2018)

Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases
por: Minakawa, Eiko N., et al.
Publicado: (2021)

Na(+)/H(+) Exchangers Induce Autophagy in Neurons and Inhibit Polyglutamine-Induced Aggregate Formation
por: Togashi, Kazuya, et al.
Publicado: (2013)

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
por: Wang, Adrienne M., et al.
Publicado: (2012)

HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease(1)
por: Howarth, Joanna L, et al.
Publicado: (2009)

Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions
por: Zhang, Xiaoman, et al.
Publicado: (2022)

Contribution of Dysferlin Deficiency to Skeletal Muscle Pathology in Asymptomatic and Severe Dystroglycanopathy Models: Generation of a New Model for Fukuyama Congenital Muscular Dystrophy
por: Kanagawa, Motoi, et al.
Publicado: (2014)

Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model
por: Cushman-Nick, Mimi, et al.
Publicado: (2013)

Autophagy and polyglutamine diseases
por: Jimenez-Sanchez, Maria, et al.
Publicado: (2012)

Polyglutamine Repeats in Viruses
por: Schein, Catherine H.
Publicado: (2018)

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
por: Reidy, Michael, et al.
Publicado: (2014)

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1
por: Harding, Rachel J., et al.
Publicado: (2021)

Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability
por: Hashimoto, Makoto, et al.
Publicado: (2018)

An Exploration of the Universe of Polyglutamine Structures
por: Gómez-Sicilia, Àngel, et al.
Publicado: (2015)

Bacterial Hsp90 Facilitates the Degradation of Aggregation-Prone Hsp70–Hsp40 Substrates
por: Fauvet, Bruno, et al.
Publicado: (2021)

Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity
por: Ghosh, Baijayanti, et al.
Publicado: (2021)

Polyglutamine-Rich Suppressors of Huntingtin Toxicity Act Upstream of Hsp70 and Sti1 in Spatial Quality Control of Amyloid-Like Proteins
por: Wolfe, Katie J., et al.
Publicado: (2014)

Skeletal Muscle Pathogenesis in Polyglutamine Diseases
por: Marchioretti, Caterina, et al.
Publicado: (2022)

Variant‐specific and reciprocal Hsp40 functions in Hsp104‐mediated prion elimination
por: Astor, Michael T., et al.
Publicado: (2018)

Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage
por: Sudo, Atsushi, et al.
Publicado: (2018)

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone
por: He, Wen-Tian, et al.
Publicado: (2016)

Hsp104-dependent ability to assimilate mannitol and sorbitol conferred by a truncated Cyc8 with a C-terminal polyglutamine in Saccharomyces cerevisiae
por: Tanaka, Hideki, et al.
Publicado: (2020)

Mitochondrial HSP70, HSP40, and HSP60 bind to the 3′ untranslated region of the Murine hepatitis virus genome
por: Nanda, S. K., et al.
Publicado: (2003)

Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer’s Disease
por: Minakawa, Eiko N., et al.
Publicado: (2019)

An Engineered Viral Protease Exhibiting Substrate Specificity for a Polyglutamine Stretch Prevents Polyglutamine-Induced Neuronal Cell Death
por: Sellamuthu, Saravanan, et al.
Publicado: (2011)

Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation
por: Fischer, David F., et al.
Publicado: (2022)

Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110
por: Kuo, Y, et al.
Publicado: (2013)

DnaJ/Hsp40 Family and Parkinson's Disease
por: Hasegawa, Takafumi, et al.
Publicado: (2018)

Protein arginylation regulates cellular stress response by stabilizing HSP70 and HSP40 transcripts
por: Deka, Kamalakshi, et al.
Publicado: (2016)

Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins
por: Jores, Tobias, et al.
Publicado: (2018)

Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents
por: Nitzsche, Bianca, et al.
Publicado: (2023)

The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins
por: Torrente, Mariana P, et al.
Publicado: (2013)

Polyglutamine Leads to Altered Chromatin Architecture and Neurodegeneration
por: Robinson, Richard
Publicado: (2006)

Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases
por: Khare, Sagar D, et al.
Publicado: (2005)

Nuclear accumulation of polyglutamine disease proteins and neuropathology
por: Havel, Lauren S, et al.
Publicado: (2009)

Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity
por: Tang, Matthew Y., et al.
Publicado: (2010)

Oligonucleotide-based strategies to combat polyglutamine diseases
por: Fiszer, Agnieszka, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_q3fr3me64f7k7mi7b7av858v2e