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Cytosolic, Autocrine Alpha-1 Proteinase Inhibitor (A1PI) Inhibits Caspase-1 and Blocks IL-1β Dependent Cytokine Release in Monocytes

RATIONALE: Activation state-dependent secretion of alpha-1 proteinase inhibitor (A1PI) by monocytes and macrophages was first reported in 1985. Since then, monocytes and tissue macrophages have emerged as key sentinels of infection and tissue damage via activation of self-assembling pattern recognit...

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Detalles Bibliográficos
Autores principales:	Wang, Yonggang, He, Yong, Abraham, Bindu, Rouhani, Farshid N., Brantly, Mark L., Scott, Dorothy E., Reed, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511367/ https://www.ncbi.nlm.nih.gov/pubmed/23226468 http://dx.doi.org/10.1371/journal.pone.0051078

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