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Genetic Loss of Murine Pyrin, the Familial Mediterranean Fever Protein, Increases Interleukin-1β Levels

Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder characterized by unprovoked episodes of fever and inflammation. The associated gene, MEFV (Mediterranean Fever), is expressed primarily by cells of myeloid lineage and encodes the protein pyrin/TRIM20/Marenostrin. The mecha...

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Detalles Bibliográficos
Autores principales:	Hesker, Pamela R., Nguyen, MyTrang, Kovarova, Martina, Ting, Jenny P.-Y., Koller, Beverly H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511413/ https://www.ncbi.nlm.nih.gov/pubmed/23226472 http://dx.doi.org/10.1371/journal.pone.0051105

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