Cargando…

Silodosin Inhibits Noradrenaline-Activated Transcription Factors Elk1 and SRF in Human Prostate Smooth Muscle

BACKGROUND: The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin. Activation of Elk1 and SRF results in bin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hennenberg, Martin, Strittmatter, Frank, Beckmann, Christer, Rutz, Beata, Füllhase, Claudius, Waidelich, Raphaela, Montorsi, Francesco, Hedlund, Petter, Andersson, Karl-Erik, Stief, Christian G., Gratzke, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511420/ https://www.ncbi.nlm.nih.gov/pubmed/23226423 http://dx.doi.org/10.1371/journal.pone.0050904

Ejemplares similares

The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction
por: Hennenberg, Martin, et al.
Publicado: (2013)

P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate
por: Wang, Yiming, et al.
Publicado: (2016)

Honokiol, a constituent of Magnolia species, inhibits adrenergic contraction of human prostate strips and induces stromal cell death
por: Herrmann, Daniel, et al.
Publicado: (2014)

Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766
por: Li, Bingsheng, et al.
Publicado: (2020)

Ghrelin Aggravates Prostate Enlargement in Rats with Testosterone-Induced Benign Prostatic Hyperplasia, Stromal Cell Proliferation, and Smooth Muscle Contraction in Human Prostate Tissues
por: Wang, Xiaolong, et al.
Publicado: (2019)

Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists
por: Spek, Annabel, et al.
Publicado: (2021)

Concentration-dependent alpha(1)-Adrenoceptor Antagonism and Inhibition of Neurogenic Smooth Muscle Contraction by Mirabegron in the Human Prostate
por: Huang, Ru, et al.
Publicado: (2021)

Inhibition of α(1)-Adrenergic, Non-Adrenergic and Neurogenic Human Prostate Smooth Muscle Contraction and of Stromal Cell Growth by the Isoflavones Genistein and Daidzein
por: Huang, Ru, et al.
Publicado: (2022)

Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases
por: Hennenberg, Martin, et al.
Publicado: (2018)

Detection of prostate cancer with complexed PSA and complexed/total PSA ratio - is there any advantage?
por: Strittmatter, F, et al.
Publicado: (2011)

Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
por: Liu, Yuhan, et al.
Publicado: (2023)

Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729
por: Huang, Ru, et al.
Publicado: (2022)

Pharmacology of the lower urinary tract
por: Hennenberg, Martin, et al.
Publicado: (2014)

Local epidemiology and resistance profiles in acute uncomplicated cystitis (AUC) in women: a prospective cohort study in an urban urological ambulatory setting
por: Seitz, Michael, et al.
Publicado: (2017)

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway
por: Li, Shang-Ze, et al.
Publicado: (2022)

Regulation of smooth muscle contraction by monomeric non‐RhoA GTPases
por: Li, Bingsheng, et al.
Publicado: (2020)

Clinically Meaningful Improvements in LUTS/BPH Severity in Men Treated with Silodosin Plus Hexanic Extract of Serenoa Repens or Silodosin Alone
por: Boeri, Luca, et al.
Publicado: (2017)

Efficacy and safety of Ho:YAG Laser Lithotripsy for ureteroscopic removal of proximal and distal ureteral calculi
por: Khoder, Wael Y, et al.
Publicado: (2014)

Picotamide inhibits a wide spectrum of agonist‐induced smooth muscle contractions in porcine renal interlobar and coronary arteries
por: Li, Bingsheng, et al.
Publicado: (2021)

Prospective comparison of one year follow-up outcomes for the open complete intrafascial retropubic versus interfascial nerve-sparing radical prostatectomy
por: Khoder, Wael Y, et al.
Publicado: (2014)

MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages
por: Xie, Lan
Publicado: (2014)

Gender Bias in Urology: How Do Patients Really Choose Their Urologist?
por: Tamalunas, Alexander, et al.
Publicado: (2022)

Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression
por: Kasza, Aneta, et al.
Publicado: (2010)

Silodosin in the treatment of benign prostatic hyperplasia
por: Rossi, Maxime, et al.
Publicado: (2010)

Management of benign prostatic hyperplasia with silodosin
por: Yamanishi, Tomonori, et al.
Publicado: (2009)

Focus on Silodosin: Pros and Cons of Uroselectivity
por: Califano, Gianluigi, et al.
Publicado: (2020)

Inhibition of Human Prostate and Bladder Smooth Muscle Contraction, Vasoconstriction of Porcine Renal and Coronary Arteries, and Growth-Related Functions of Prostate Stromal Cells by Presumed Small Molecule Gα(q/11) Inhibitor, YM-254890
por: Tamalunas, Alexander, et al.
Publicado: (2022)

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
por: Xu, Yue, et al.
Publicado: (2023)

A Suspected Case of Silodosin-Induced Erythroderma
por: Liu, Annie, et al.
Publicado: (2015)

Silodosin-associated intraoperative floppy iris syndrome
por: Chatterjee, Samrat, et al.
Publicado: (2017)

Comparing tamsulosin, silodosin versus silodosin plus tadalafil as medical expulsive therapy for lower ureteric stones: A randomised trial
por: Rahman, Md Jawaid, et al.
Publicado: (2017)

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter
por: Nilsson, Maria, et al.
Publicado: (2008)

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter
por: Nilsson, Maria, et al.
Publicado: (2007)

Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies
por: Nagashima, Shun, et al.
Publicado: (2019)

Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
por: Yoshida, Masaki, et al.
Publicado: (2011)

Investigation of ejaculatory disorder by silodosin in the treatment of prostatic hyperplasia
por: Sakata, Koichi, et al.
Publicado: (2012)

Noradrenaline and Parkinson's Disease
por: Delaville, Claire, et al.
Publicado: (2011)

Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell
por: Kitagawa, Atsushi, et al.
Publicado: (2022)

HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
por: Zhang, Mengxue, et al.
Publicado: (2018)

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
por: Horita, Henrick, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dqdg8poqfl59nk1n22hh1cilca