Cargando…

A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment

Somatic Nucleophosmin (NPM1) mutation frequently occurs in acute myeloid leukemia (AML), but its role in leukemogenesis remains unclear. This study reports the first “conventional” knock-in mouse model of Npm1 mutation, which was achieved by inserting TCTG after nucleotide c.857 (c.854_857dupTCTG) t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, Shiu-Huey, Ko, Bor-Sheng, Chiou, Ji-Shain, Hsu, Yueh-Chwen, Tsai, Mong-Hsun, Chiu, Yu-Chiao, Yu, I-Shing, Lin, Shu-Wha, Hou, Hsin-An, Kuo, Yi-Yi, Lin, Hsiu-Mei, Wu, Ming-Fang, Chou, Wen-Chien, Tien, Hwei-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511491/ https://www.ncbi.nlm.nih.gov/pubmed/23226219 http://dx.doi.org/10.1371/journal.pone.0049769

Ejemplares similares

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
por: Tripodo, Claudio, et al.
Publicado: (2022)

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model
por: Hsu, Yueh-Chwen, et al.
Publicado: (2017)

Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction
por: Verboon, Jeffrey M., et al.
Publicado: (2020)

Hierarchical cluster analysis of immunophenotype classify AML patients with NPM1 gene mutation into two groups with distinct prognosis
por: Chen, Chien-Yuan, et al.
Publicado: (2013)

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression
por: Klein, Claudius, et al.
Publicado: (2016)

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
por: Thiel, V N, et al.
Publicado: (2017)

Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
por: Villatoro, Alicia, et al.
Publicado: (2023)

Palbociclib Promotes Dephosphorylation of NPM/B23 at Threonine 199 and Inhibits Endometrial Cancer Cell Growth
por: Lin, Chiao-Yun, et al.
Publicado: (2019)

High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia
por: Lee, Sze-Hwei, et al.
Publicado: (2017)

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
por: Boldin, Mark P., et al.
Publicado: (2011)

Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
por: Ng, Ashley P., et al.
Publicado: (2015)

Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
por: Villatoro, Alicia, et al.
Publicado: (2023)

Dnmt3a Regulates Myeloproliferation and Liver-Specific Expansion of Hematopoietic Stem and Progenitor Cells
por: Guryanova, Olga A., et al.
Publicado: (2015)

Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation
por: Hamarsheh, Shaima’a, et al.
Publicado: (2020)

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation
por: Mead, Adam J., et al.
Publicado: (2017)

Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism
por: Barthelson, Karissa, et al.
Publicado: (2022)

Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemia
por: Lin, Chien-Chin, et al.
Publicado: (2017)

A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals
por: Nakagawa, Masahiro Marshall, et al.
Publicado: (2019)

A Review of SARS-CoV-2 and the Ongoing Clinical Trials
por: Tu, Yung-Fang, et al.
Publicado: (2020)

Depth-Camera Based Energy Expenditure Estimation System for Physical Activity Using Posture Classification Algorithm
por: Lin, Bor-Shing, et al.
Publicado: (2021)

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
por: McDuff, Fiona Kate Elizabeth, et al.
Publicado: (2011)

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing
por: Aitken, Marisa J L, et al.
Publicado: (2022)

Biallelic deleterious germline SH2B3 variants cause a novel syndrome of myeloproliferation and multi‐organ autoimmunity
por: Blombery, Piers, et al.
Publicado: (2023)

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
por: Xiong, Qiuhong, et al.
Publicado: (2015)

Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids
por: Ahmad Mulyadi Lai, Henkie Isahwan, et al.
Publicado: (2021)

Phlebosclerotic colitis: A case report and review of the literature
por: FANG, YUE-LIN, et al.
Publicado: (2014)

Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation
por: Song, Hui-Yung, et al.
Publicado: (2021)

mNG-tagged mls-2 knock-in alleles in C. elegans
por: Xiong, Rui, et al.
Publicado: (2022)

Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis
por: Lin, Chiao-Ming, et al.
Publicado: (2012)

A New Synthetic Compound, 2-OH, Enhances Interleukin-2 and Interferon-γ Gene Expression in Human Peripheral Blood Mononuclear Cells
por: Chou, Shiu-Huey, et al.
Publicado: (2009)

Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents
por: Wang, Lei-Chi, et al.
Publicado: (2021)

The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome
por: Yang, Yi-Tsung, et al.
Publicado: (2018)

Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice
por: Chang, Chun-Kai, et al.
Publicado: (2018)

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling
por: Okuwaki, Mitsuru, et al.
Publicado: (2012)

An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
por: Chuang, Ming-Kai, et al.
Publicado: (2015)

Efficient implied alignment
por: Washburn, Alex J., et al.
Publicado: (2020)

Express and Implied Terms
por: Wilmot-Smith, Frederick
Publicado: (2022)

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
por: Darracq, Anaïs, et al.
Publicado: (2019)

Old Habits Die Hard: A Nationwide Utilization Study of Short-Acting Nifedipine in Taiwan
por: Chou, Chia-Lin, et al.
Publicado: (2014)

Targeted therapy in NPM1-mutated AML: Knowns and unknowns
por: Wang, Rong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mhlc65g03csrv94vp6ivvsj41j