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A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment

Somatic Nucleophosmin (NPM1) mutation frequently occurs in acute myeloid leukemia (AML), but its role in leukemogenesis remains unclear. This study reports the first “conventional” knock-in mouse model of Npm1 mutation, which was achieved by inserting TCTG after nucleotide c.857 (c.854_857dupTCTG) t...

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Detalles Bibliográficos
Autores principales:	Chou, Shiu-Huey, Ko, Bor-Sheng, Chiou, Ji-Shain, Hsu, Yueh-Chwen, Tsai, Mong-Hsun, Chiu, Yu-Chiao, Yu, I-Shing, Lin, Shu-Wha, Hou, Hsin-An, Kuo, Yi-Yi, Lin, Hsiu-Mei, Wu, Ming-Fang, Chou, Wen-Chien, Tien, Hwei-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511491/ https://www.ncbi.nlm.nih.gov/pubmed/23226219 http://dx.doi.org/10.1371/journal.pone.0049769

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