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Structural Requirements for the Procoagulant Activity of Nucleic Acids

Nucleic acids, especially extracellular RNA, are exposed following tissue- or vessel damage and have previously been shown to activate the intrinsic blood coagulation pathway in vitro and in vivo. Yet, no information on structural requirements for the procoagulant activity of nucleic acids is availa...

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Detalles Bibliográficos
Autores principales: Gansler, Julia, Jaax, Miriam, Leiting, Silke, Appel, Bettina, Greinacher, Andreas, Fischer, Silvia, Preissner, Klaus T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511531/
https://www.ncbi.nlm.nih.gov/pubmed/23226277
http://dx.doi.org/10.1371/journal.pone.0050399