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Oxidative Stress Induces Nuclear-to-Cytosol Shift of hMSH3, a Potential Mechanism for EMAST in Colorectal Cancer Cells

BACKGROUND: Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is a genetic signature observed in 60% of sporadic colorectal cancers (CRCs). Unlike microsatellite unstable CRCs where hypermethylation of the DNA mismatch repair (MMR) gene hMLH1’s promoter is causal, the p...

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Detalles Bibliográficos
Autores principales:	Tseng-Rogenski, Stephanie S., Chung, Heekyung, Wilk, Maike B., Zhang, Shuai, Iwaizumi, Moriya, Carethers, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511561/ https://www.ncbi.nlm.nih.gov/pubmed/23226332 http://dx.doi.org/10.1371/journal.pone.0050616

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