Gene Silencing Mediated by siRNA-binding Fusion Proteins Is Attenuated by Double-stranded RNA-binding Domain Structure

Delivery of small interfering RNA (siRNA) targeted to specific cell types is a significant challenge for the development of RNA interference-based therapeutics. Recently, PTD-DRBD, a double-stranded RNA binding domain (DRBD) fused to the TAT protein transduction domain (PTD), was shown to be effecti...

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Detalles Bibliográficos
Autores principales: Geoghegan, James C, Gilmore, Brian L, Davidson, Beverly L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511671/
https://www.ncbi.nlm.nih.gov/pubmed/23629028
http://dx.doi.org/10.1038/mtna.2012.43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511671/
https://www.ncbi.nlm.nih.gov/pubmed/23629028
http://dx.doi.org/10.1038/mtna.2012.43

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