Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract,...

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Autores principales: Batra, Vinita, Syed, Zanobia, Gill, Jennifer N, Coburn, Malari A, Adegboyega, Patrick, DiGiovanni, John, Mathis, J Michael, Shi, Runhua, Clifford, John L, Kleiner-Hancock, Heather E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511812/
https://www.ncbi.nlm.nih.gov/pubmed/22704648
http://dx.doi.org/10.1186/1756-9966-31-57
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author Batra, Vinita
Syed, Zanobia
Gill, Jennifer N
Coburn, Malari A
Adegboyega, Patrick
DiGiovanni, John
Mathis, J Michael
Shi, Runhua
Clifford, John L
Kleiner-Hancock, Heather E
author_facet Batra, Vinita
Syed, Zanobia
Gill, Jennifer N
Coburn, Malari A
Adegboyega, Patrick
DiGiovanni, John
Mathis, J Michael
Shi, Runhua
Clifford, John L
Kleiner-Hancock, Heather E
author_sort Batra, Vinita
collection PubMed
description The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr(705)Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.
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spelling pubmed-35118122012-12-02 Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice Batra, Vinita Syed, Zanobia Gill, Jennifer N Coburn, Malari A Adegboyega, Patrick DiGiovanni, John Mathis, J Michael Shi, Runhua Clifford, John L Kleiner-Hancock, Heather E J Exp Clin Cancer Res Research The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr(705)Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action. BioMed Central 2012-06-15 /pmc/articles/PMC3511812/ /pubmed/22704648 http://dx.doi.org/10.1186/1756-9966-31-57 Text en Copyright ©2012 Batra et al. licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Batra, Vinita
Syed, Zanobia
Gill, Jennifer N
Coburn, Malari A
Adegboyega, Patrick
DiGiovanni, John
Mathis, J Michael
Shi, Runhua
Clifford, John L
Kleiner-Hancock, Heather E
Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice
title Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice
title_full Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice
title_fullStr Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice
title_full_unstemmed Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice
title_short Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice
title_sort effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in k5.stat3c transgenic mice
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511812/
https://www.ncbi.nlm.nih.gov/pubmed/22704648
http://dx.doi.org/10.1186/1756-9966-31-57
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