PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H(1) receptor

Histamine H(1) receptor (H1R) gene is up-regulated in patients with allergic rhinitis, and its expression level strongly correlates with the severity of symptoms. However, the mechanism underlying this remains unknown. Here we report the mechanism of H1R gene up-regulation. The luciferase assay reve...

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Detalles Bibliográficos
Autores principales: Mizuguchi, Hiroyuki, Miyagi, Kohei, Terao, Takuma, Sakamoto, Noriko, Yamawaki, Yosuke, Adachi, Tsubasa, Ono, Shohei, Sasaki, Yohei, Yoshimura, Yoshiyuki, Kitamura, Yoshiaki, Takeda, Noriaki, Fukui, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512088/
https://www.ncbi.nlm.nih.gov/pubmed/23209876
http://dx.doi.org/10.1038/srep00916

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