Targeting of >1.5 Mb of Human DNA into the Mouse X Chromosome Reveals Presence of cis-Acting Regulators of Epigenetic Silencing

Regulatory sequences can influence the expression of flanking genes over long distances, and X chromosome inactivation is a classic example of cis-acting epigenetic gene regulation. Knock-ins directed to the Mus musculus Hprt locus offer a unique opportunity to analyze the spread of silencing into d...

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Detalles Bibliográficos
Autores principales: Yang, Christine, McLeod, Andrea J., Cotton, Allison M., de Leeuw, Charles N., Laprise, Stéphanie, Banks, Kathleen G., Simpson, Elizabeth M., Brown, Carolyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2012
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512139/
https://www.ncbi.nlm.nih.gov/pubmed/23023002
http://dx.doi.org/10.1534/genetics.112.143743

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