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Antioxidant Therapy in Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achi...

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Detalles Bibliográficos
Autores principales: Al-Busafi, Said A., Bhat, Mamatha, Wong, Philip, Ghali, Peter, Deschenes, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512254/
https://www.ncbi.nlm.nih.gov/pubmed/23227320
http://dx.doi.org/10.1155/2012/947575
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author Al-Busafi, Said A.
Bhat, Mamatha
Wong, Philip
Ghali, Peter
Deschenes, Marc
author_facet Al-Busafi, Said A.
Bhat, Mamatha
Wong, Philip
Ghali, Peter
Deschenes, Marc
author_sort Al-Busafi, Said A.
collection PubMed
description Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.
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spelling pubmed-35122542012-12-07 Antioxidant Therapy in Nonalcoholic Steatohepatitis Al-Busafi, Said A. Bhat, Mamatha Wong, Philip Ghali, Peter Deschenes, Marc Hepat Res Treat Review Article Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH. Hindawi Publishing Corporation 2012 2012-11-22 /pmc/articles/PMC3512254/ /pubmed/23227320 http://dx.doi.org/10.1155/2012/947575 Text en Copyright © 2012 Said A. Al-Busafi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Al-Busafi, Said A.
Bhat, Mamatha
Wong, Philip
Ghali, Peter
Deschenes, Marc
Antioxidant Therapy in Nonalcoholic Steatohepatitis
title Antioxidant Therapy in Nonalcoholic Steatohepatitis
title_full Antioxidant Therapy in Nonalcoholic Steatohepatitis
title_fullStr Antioxidant Therapy in Nonalcoholic Steatohepatitis
title_full_unstemmed Antioxidant Therapy in Nonalcoholic Steatohepatitis
title_short Antioxidant Therapy in Nonalcoholic Steatohepatitis
title_sort antioxidant therapy in nonalcoholic steatohepatitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512254/
https://www.ncbi.nlm.nih.gov/pubmed/23227320
http://dx.doi.org/10.1155/2012/947575
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