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Functional divergence of gene duplicates through ectopic recombination

Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic re...

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Autores principales: Christiaens, Joaquin F, Van Mulders, Sebastiaan E, Duitama, Jorge, Brown, Chris A, Ghequire, Maarten G, De Meester, Luc, Michiels, Jan, Wenseleers, Tom, Voordeckers, Karin, Verstrepen, Kevin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512402/
https://www.ncbi.nlm.nih.gov/pubmed/23070367
http://dx.doi.org/10.1038/embor.2012.157
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author Christiaens, Joaquin F
Van Mulders, Sebastiaan E
Duitama, Jorge
Brown, Chris A
Ghequire, Maarten G
De Meester, Luc
Michiels, Jan
Wenseleers, Tom
Voordeckers, Karin
Verstrepen, Kevin J
author_facet Christiaens, Joaquin F
Van Mulders, Sebastiaan E
Duitama, Jorge
Brown, Chris A
Ghequire, Maarten G
De Meester, Luc
Michiels, Jan
Wenseleers, Tom
Voordeckers, Karin
Verstrepen, Kevin J
author_sort Christiaens, Joaquin F
collection PubMed
description Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation.
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spelling pubmed-35124022012-12-03 Functional divergence of gene duplicates through ectopic recombination Christiaens, Joaquin F Van Mulders, Sebastiaan E Duitama, Jorge Brown, Chris A Ghequire, Maarten G De Meester, Luc Michiels, Jan Wenseleers, Tom Voordeckers, Karin Verstrepen, Kevin J EMBO Rep Scientific Reports Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation. European Molecular Biology Organization 2012-12 2012-10-16 /pmc/articles/PMC3512402/ /pubmed/23070367 http://dx.doi.org/10.1038/embor.2012.157 Text en Copyright © 2012, European Molecular Biology Organization https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
spellingShingle Scientific Reports
Christiaens, Joaquin F
Van Mulders, Sebastiaan E
Duitama, Jorge
Brown, Chris A
Ghequire, Maarten G
De Meester, Luc
Michiels, Jan
Wenseleers, Tom
Voordeckers, Karin
Verstrepen, Kevin J
Functional divergence of gene duplicates through ectopic recombination
title Functional divergence of gene duplicates through ectopic recombination
title_full Functional divergence of gene duplicates through ectopic recombination
title_fullStr Functional divergence of gene duplicates through ectopic recombination
title_full_unstemmed Functional divergence of gene duplicates through ectopic recombination
title_short Functional divergence of gene duplicates through ectopic recombination
title_sort functional divergence of gene duplicates through ectopic recombination
topic Scientific Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512402/
https://www.ncbi.nlm.nih.gov/pubmed/23070367
http://dx.doi.org/10.1038/embor.2012.157
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