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Functional divergence of gene duplicates through ectopic recombination
Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic re...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Molecular Biology Organization
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512402/ https://www.ncbi.nlm.nih.gov/pubmed/23070367 http://dx.doi.org/10.1038/embor.2012.157 |
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author | Christiaens, Joaquin F Van Mulders, Sebastiaan E Duitama, Jorge Brown, Chris A Ghequire, Maarten G De Meester, Luc Michiels, Jan Wenseleers, Tom Voordeckers, Karin Verstrepen, Kevin J |
author_facet | Christiaens, Joaquin F Van Mulders, Sebastiaan E Duitama, Jorge Brown, Chris A Ghequire, Maarten G De Meester, Luc Michiels, Jan Wenseleers, Tom Voordeckers, Karin Verstrepen, Kevin J |
author_sort | Christiaens, Joaquin F |
collection | PubMed |
description | Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation. |
format | Online Article Text |
id | pubmed-3512402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | European Molecular Biology Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-35124022012-12-03 Functional divergence of gene duplicates through ectopic recombination Christiaens, Joaquin F Van Mulders, Sebastiaan E Duitama, Jorge Brown, Chris A Ghequire, Maarten G De Meester, Luc Michiels, Jan Wenseleers, Tom Voordeckers, Karin Verstrepen, Kevin J EMBO Rep Scientific Reports Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation. European Molecular Biology Organization 2012-12 2012-10-16 /pmc/articles/PMC3512402/ /pubmed/23070367 http://dx.doi.org/10.1038/embor.2012.157 Text en Copyright © 2012, European Molecular Biology Organization https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission. |
spellingShingle | Scientific Reports Christiaens, Joaquin F Van Mulders, Sebastiaan E Duitama, Jorge Brown, Chris A Ghequire, Maarten G De Meester, Luc Michiels, Jan Wenseleers, Tom Voordeckers, Karin Verstrepen, Kevin J Functional divergence of gene duplicates through ectopic recombination |
title | Functional divergence of gene duplicates through ectopic recombination |
title_full | Functional divergence of gene duplicates through ectopic recombination |
title_fullStr | Functional divergence of gene duplicates through ectopic recombination |
title_full_unstemmed | Functional divergence of gene duplicates through ectopic recombination |
title_short | Functional divergence of gene duplicates through ectopic recombination |
title_sort | functional divergence of gene duplicates through ectopic recombination |
topic | Scientific Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512402/ https://www.ncbi.nlm.nih.gov/pubmed/23070367 http://dx.doi.org/10.1038/embor.2012.157 |
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