378 Aspirin Desensitization Treatment: A Case Report

BACKGROUND: Aspirin (ASA) is one of the best known and most widely used drugs in the world. Patients with coronary artery disease require prolonged treatments with this drug, which is denied to those patients with histories of adverse reactions to it. METHODS: In a rapid desensitization protocol a patient with a history of ASA-induced urticaria-angioedema was treated with escalating doses of aspirin administered orally every 25 minutes. RESULTS: The patient completed the desensitization protocol in few hours without complications, and currently is able to take 125 mg of ASA per day without adverse reactions. CONCLUSIONS: This report describes the first desensitization treatment with aspirin carried out in our hospital. No other case was found in the national bibliography.