551 The Impact of Nasal Polyposis on Quality of Life Using the Eq-5d Health Profile

BACKGROUND: Even though nasal polyposis (NP) is not a severe life-threatening disease, it has a considerable negative impact on health-related quality of life (HRQL). The goal of this study was to analyze HRQL in a large sample of patients with NP compared to the general population in Spain. METHODS: The EQ-5D survey, which includes a descriptive system and is composed of 5 dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), and the EQ visual analog scale (EQ VAS) were applied to patients with NP. RESULTS: NP patients (N = 1,170; mean age 49 ± 15 yr, 35.5% female) completed the questionnaire. NP patients had a lower EQ VAS score (63.8 ± 21.5; P < 0.05) than the general population (71.3). NP patients having some or extreme problems reported higher overall percentages for all EQ-5D domains: mobility (13.3, P < 0.05), self-care (8.2, P < 0.05), usual activities (26.6, P < 0.05), pain/discomfort (55.6, P < 0.05), and anxiety/depression (32.6, P < 0.05, compared with the general population (10.9, 2.0, 6.4, 25.8, and 13.7, respectively). Mean EQ-5D index values (0.78 ± 0.24) were also lower than the general population (0.89; P < 0.05). There were no differences between mean EQ-5D index values when gender, age group, or tobacco consumption was compared. CONCLUSIONS: These results confirm, by using EQ-5D questionnaire, that nasal polyposis has a negative impact on HRQL compared to the general population.