380 Presentation of Three Cases of Allergic Reactions to Triptorelin

BACKGROUND: Triptorelin is a drug that is frequently used in pediatrics to treat precocious puberty -an often condition in childhood endocrinology services. Despite its widespread use, there is not much research on hypersensitivity reactions to this drug. We found 3 patients that have suffered allergic reaction during the treatment with Triptorelin. METHODS: We treated three 8 year old girls diagnosed with precocious puberty that have suffered allergic reaction during the treatment with Triptorelin. Patient 1: An hour after the first dose the patient broke out in a rash over her face, trunk and upper limbs. She also showed general paleness, conjunctival erythema, arthralgia and joint swelling in both knees with functional impotence of the lower limbs. Patient 2: Five minutes after the second dose the patient showed anaphylactic reaction. Patient 3: Two hours after the second dose the patient showed generalized urticaria and tachycardia. RESULTS: Once overcome those events. We started to provoke the reaction by doing the progressive-controlled triptorelin test. Finally we could confirm the hypersensitivity reaction to this drug CONCLUSIONS: The triptorelin is a drug that may cause hypersensitivity reaction. So, after the first application, we recommend to monitor the patient and also plan some actions to avoid a possible anaphylactic shock event.