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297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid
BACKGROUND: While asthma control is defined as the extent to which the various manifestations of asthma are reduced by treatment, current guidelines of asthma recommend assessment of asthma control without consideration of airway inflammation. Our aim was to investigate the relationships between fra...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization Journal
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512760/ http://dx.doi.org/10.1097/01.WOX.0000412054.05318.f5 |
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author | Yoon, Ho Joo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Chang, Suk-Il |
author_facet | Yoon, Ho Joo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Chang, Suk-Il |
author_sort | Yoon, Ho Joo |
collection | PubMed |
description | BACKGROUND: While asthma control is defined as the extent to which the various manifestations of asthma are reduced by treatment, current guidelines of asthma recommend assessment of asthma control without consideration of airway inflammation. Our aim was to investigate the relationships between fractional exhaled nitric oxide (FeNO), a reliable marker of airway inflammation, and levels of asthma controls in patients treated with inhaled corticosteroid (ICS). METHODS: We enrolled 71 adult patients with asthma, who had been treated with ICS more than 4 months. Asthma control was assessed by the physician based on the Global Initiative for Asthma guidelines, and by the patients and by using Asthma Control Test (ACT). Statistical analyses were performed to analyze the relationships between FeNO and measures of asthma control and clinical indices for asthma manifestations. RESULTS: There was no significant difference in FeNO levels between 3 groups according to levels of asthma control (controlled, partly controlled and uncontrolled) determined by the physician (P = 0.81) and by the patients (P = 0.81). In addition, FeNO values were not correlated with the ACT scores (r = 0.031, P = 0.807), while FeNO showed peripheral blood eosinophil counts (P < 0.001). CONCLUSIONS: These findings demonstrated that FeNO levels are not related with the measures of asthma control in patients treated with ICS. Information of airway inflammation from FeNO concentrations seems to be discrepant from levels of asthma control. |
format | Online Article Text |
id | pubmed-3512760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | World Allergy Organization Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-35127602012-12-21 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid Yoon, Ho Joo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Chang, Suk-Il World Allergy Organ J Abstracts of the XXII World Allergy Congress BACKGROUND: While asthma control is defined as the extent to which the various manifestations of asthma are reduced by treatment, current guidelines of asthma recommend assessment of asthma control without consideration of airway inflammation. Our aim was to investigate the relationships between fractional exhaled nitric oxide (FeNO), a reliable marker of airway inflammation, and levels of asthma controls in patients treated with inhaled corticosteroid (ICS). METHODS: We enrolled 71 adult patients with asthma, who had been treated with ICS more than 4 months. Asthma control was assessed by the physician based on the Global Initiative for Asthma guidelines, and by the patients and by using Asthma Control Test (ACT). Statistical analyses were performed to analyze the relationships between FeNO and measures of asthma control and clinical indices for asthma manifestations. RESULTS: There was no significant difference in FeNO levels between 3 groups according to levels of asthma control (controlled, partly controlled and uncontrolled) determined by the physician (P = 0.81) and by the patients (P = 0.81). In addition, FeNO values were not correlated with the ACT scores (r = 0.031, P = 0.807), while FeNO showed peripheral blood eosinophil counts (P < 0.001). CONCLUSIONS: These findings demonstrated that FeNO levels are not related with the measures of asthma control in patients treated with ICS. Information of airway inflammation from FeNO concentrations seems to be discrepant from levels of asthma control. World Allergy Organization Journal 2012-02-17 /pmc/articles/PMC3512760/ http://dx.doi.org/10.1097/01.WOX.0000412054.05318.f5 Text en Copyright © 2012 by World Allergy Organization |
spellingShingle | Abstracts of the XXII World Allergy Congress Yoon, Ho Joo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Chang, Suk-Il 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid |
title | 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid |
title_full | 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid |
title_fullStr | 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid |
title_full_unstemmed | 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid |
title_short | 297 Relationship Between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid |
title_sort | 297 relationship between exhaled nitric oxide and levels of asthma control in asthma patients treated with inhaled corticosteroid |
topic | Abstracts of the XXII World Allergy Congress |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512760/ http://dx.doi.org/10.1097/01.WOX.0000412054.05318.f5 |
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