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501 Activation of PAR-2 Induces Myofibroblast Transformation via a TGF-β and GSK-3β/β-catenin Dependent Pathway in Tissue Remodeling in the Asthmatic Lung

BACKGROUND: Asthma is a chronic inflammatory lung disease, and airway remodeling denotes the pathophysiologic modifications of normal airway wall structure, including changes in the composition and organization of the airway wall's cellular and molecular constituents. These structural alteratio...

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Detalles Bibliográficos
Autores principales: Suzuki, Tomoko, Downey, Gregory, Nakagome, Kazuyuki, Nagata, Makoto, Hagiwara, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512798/
http://dx.doi.org/10.1097/01.WOX.0000411616.11421.94