474 Relationship Between Total Serum IgE, Atopy, and Obesity in Children With or Without Family History of Atopic Disease

BACKGROUND: Prevalence of obesity and atopy had been increased simultanoeuosly. The relationship between obesity, atopy, and total serum IgE had been estimated. The aim of this study is to find out the relationship between total serum Ig E, atopy, and obese children with or without family history of atopic disease. METHODS: This was a cross sectional study. There were 160 children aged 6 to 11 years which were divided into 4 groups: obese children with and without family history of atopic disease and normal weight children with and without family history of atopic disease. Atopic was defined by positive result of one of allergens skin prick test and ECLIA method were done for total serum IgE. Significancy for categorical data used Chi-Square test. Logistic regression model were used to examine the relationship between obesity, total serum IgE, and atopy. RESULTS: We measured the total serum IgE of 155 children. The number of obese and normal weight children with family history of atopic disease who had high level of total serum IgE were 30 and 25 respectively, whereas these children who had normal level of total serum IgE were 6 and 15 respectively [OR = 1.9 (95% CI 0.9-3.9)]. On the other hand, obese and normal weight children without family history of atopic disease who had high level of total serum IgE were 21 and 11 respectively, whereas these children who had normal level of total serum IgE were 18 and 29 respectively [OR = 1.7 (95% CI 1.1-2.7)]. The number of obese and normal weight children without family history of atopic disease who had atopy were 38 and 9 respectively, whereas these children who had non-atopy were 2 and 31 respectively [OR = 13.3 (95% CI 3.5-52)], but there was no relationship between atopy and obesity in group with family history of atopic disease (P = 0.314). CONCLUSIONS: There were relationship between high level of total serum IgE and obesity in group with and without family history of atopic disease and also relationship between atopy and obesity in group without family history of atopic disease.