599 Prevalence of Common Variable Immunodeficiency in Adult Patients Specialty Hospital—Centro Medico Nacional Siglo XXI - Mss—Mexico City

BACKGROUND: Common Variable Immunodeficiency (CVID) is the most common primary immunodeficiency (IDP), occurs primarily in adults between the second to fourth decades of life, without gender predominance. It is characterized by concentrations of immunoglobulins (Igs) of at least 2 standard deviation (DS) of normal, recurring infections, some patients have autoimmune diseases and tumors, absence of isohemagglutinins and lack of production of antibodies (Ab) after vaccination and have excluded other causes of hypogammaglobulinemia. OBJECTIVE: Determine the prevalence of CVID in the Specialty Hospital—Centro Medico Nacional Siglo XXI, IMSS, Mexico City. METHODS: We included all patients with suspected diagnosis of CVID, clinical history, laboratory tests, determination of serum Igs and isohemagglutinins and were given a dose of gamma globulin 500 mg/kg/dose every 21 days. The results were analyzed with descriptive statistics. The protocol was approved by the local research committee. RESULTS: A total of 15 patients, 11 women and 4 men, mean age 34 years (± 11), 14 patients met all international standards and just only one patient has positive isohemagglutinins. The prevalence of CVID calculated according to the total population that is entitled in this hospital, 1, 520, 900, 1: 101, 393. In relation to the number of patients served by our service, the prevalence of 0.053% with a ratio of 1:2.533 right holders. CONCLUSIONS: Our results show differences in relation to the published literature, prevalence in female sex ratio of 3:1, participating patients were diagnosed at the 34 years of average age, just only 2 patients were diagnosed before 20 years of age, unlike some of the international and national reports, we establish the definitive diagnosis according to international standards in 93% of cases evaluated. The prevalence of CVID obtained in our study is 1:101.393, higher than reported in international literature is 1:30.000 to 1:50.000, but similar to that reported in Spain in 1997 and Iran in 2006.