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353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case

BACKGROUND: Neonatal Lupus is a rare disease, described in 1954, which only occurs in children of mothers with antibodies to specific antigens of Systemic Lupus Erythematosus (SLE). Such antigens pass, transplacentally during gestation and is characterized by cutaneous manifestations such as rash, e...

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Autores principales: Pellizzeri, Aura, García, Durnes, Torres, Joselit, Martínez, Mayra, Chavez, Elianny, Briceño, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512969/
http://dx.doi.org/10.1097/01.WOX.0000412116.18651.41
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author Pellizzeri, Aura
García, Durnes
Torres, Joselit
Martínez, Mayra
Chavez, Elianny
Briceño, Diana
author_facet Pellizzeri, Aura
García, Durnes
Torres, Joselit
Martínez, Mayra
Chavez, Elianny
Briceño, Diana
author_sort Pellizzeri, Aura
collection PubMed
description BACKGROUND: Neonatal Lupus is a rare disease, described in 1954, which only occurs in children of mothers with antibodies to specific antigens of Systemic Lupus Erythematosus (SLE). Such antigens pass, transplacentally during gestation and is characterized by cutaneous manifestations such as rash, erythematous macules, papules or plaques which tend to coalesce; less frequent are blood disorders including aplastic anemia, neutropenia, thrombocytopenia, hemolytic anemia, pancytopenia; liver disorders with elevated liver enzymes and cholestasis; central nervous system disease such as mielopaias, convulsions; pulmonary as pneumonitis, and gastrointestinal tract such as bloody diarrhea. Alopecia is a common symptom in SLE but has not been reported in the literature in neonatal presentation. METHODS: Case report: A 1 month and 4 day old infant female, who presented 3 days after birth with a persistent bloody diarrhea, without mucus also presents dehydration and metabolic acidosis that warrant intravenous correction. An infectious etiology is discarded and is referred to an allergist for study of a possible lactose intolerance which is discarded initially. However, the physical finding of hair loss is evident with areas of alopecia which together with the persistence of the diarrhea and rash is suspect of a possible immunological etiology. Therefore, it was decided to test Anti-Ro autoimmunity in the infant and his mother; given a positive results. RESULTS: With the Anti-Ro test the presence of Neonatal Lupus is confirmed. A treatment with EV-dose methylprednisolone was initiated, which had little clinical response, meriting a treatment with azathioprine with a good clinical response, which improved and reduced Anti-Ro values. CONCLUSIONS: The importance of clinical observation is evident when there are unusual features which allows for a rare diagnosis. This striking case, given the unusual presentation with alopecia which together with the clinical observations was indicative of this disease, and not of other syndromes characteristic of this age, like sepsis.
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spelling pubmed-35129692012-12-21 353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case Pellizzeri, Aura García, Durnes Torres, Joselit Martínez, Mayra Chavez, Elianny Briceño, Diana World Allergy Organ J Abstracts of the XXII World Allergy Congress BACKGROUND: Neonatal Lupus is a rare disease, described in 1954, which only occurs in children of mothers with antibodies to specific antigens of Systemic Lupus Erythematosus (SLE). Such antigens pass, transplacentally during gestation and is characterized by cutaneous manifestations such as rash, erythematous macules, papules or plaques which tend to coalesce; less frequent are blood disorders including aplastic anemia, neutropenia, thrombocytopenia, hemolytic anemia, pancytopenia; liver disorders with elevated liver enzymes and cholestasis; central nervous system disease such as mielopaias, convulsions; pulmonary as pneumonitis, and gastrointestinal tract such as bloody diarrhea. Alopecia is a common symptom in SLE but has not been reported in the literature in neonatal presentation. METHODS: Case report: A 1 month and 4 day old infant female, who presented 3 days after birth with a persistent bloody diarrhea, without mucus also presents dehydration and metabolic acidosis that warrant intravenous correction. An infectious etiology is discarded and is referred to an allergist for study of a possible lactose intolerance which is discarded initially. However, the physical finding of hair loss is evident with areas of alopecia which together with the persistence of the diarrhea and rash is suspect of a possible immunological etiology. Therefore, it was decided to test Anti-Ro autoimmunity in the infant and his mother; given a positive results. RESULTS: With the Anti-Ro test the presence of Neonatal Lupus is confirmed. A treatment with EV-dose methylprednisolone was initiated, which had little clinical response, meriting a treatment with azathioprine with a good clinical response, which improved and reduced Anti-Ro values. CONCLUSIONS: The importance of clinical observation is evident when there are unusual features which allows for a rare diagnosis. This striking case, given the unusual presentation with alopecia which together with the clinical observations was indicative of this disease, and not of other syndromes characteristic of this age, like sepsis. World Allergy Organization Journal 2012-02-17 /pmc/articles/PMC3512969/ http://dx.doi.org/10.1097/01.WOX.0000412116.18651.41 Text en Copyright © 2012 by World Allergy Organization
spellingShingle Abstracts of the XXII World Allergy Congress
Pellizzeri, Aura
García, Durnes
Torres, Joselit
Martínez, Mayra
Chavez, Elianny
Briceño, Diana
353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case
title 353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case
title_full 353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case
title_fullStr 353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case
title_full_unstemmed 353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case
title_short 353 Alopecia as a Symptom of Neonatal Lupus: A Report of Case
title_sort 353 alopecia as a symptom of neonatal lupus: a report of case
topic Abstracts of the XXII World Allergy Congress
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512969/
http://dx.doi.org/10.1097/01.WOX.0000412116.18651.41
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