244 Nasal Poliposis and Allergic Disease. Dr. Salvador Allende Hospital

BACKGROUND: The edematous irritation of the corium of the pituitary mucosa wakes it suffers a degeneration that causes what is known as nasal polyposis, hypertrophy of the nasal mucosa as a result of a chronic inflamatory process. It is said that its formation is due to infectious processes, vascular changes as local disorders of the immunity of the nasal mucosa. However many concide in including the allergic factors as the cause of the nasal polypos and they give a special interest to the constitutional factor inside the genesis of them. The investigation had as objectives to know the relationship that there is between the nasal polyposis and the allergic diseases, as well as to study some parameters of the humoral and celular immunity in our patients. METHODS: 15 patients diagnosed wiht nasal polyposis were taken from the otorhinolaryngologists and they were sent to the allergic department to be evaluated. Patient's charts of all of thems were made and they were indicated some studies such as eosinophil global count, nasal exudate,sample radiographic study of paranasal sinus, serology, hemogram, glycemia and minimal clotting test, study of the humoral immunity and making determination of IgE, IgA, IgG, IgM. The celular immunity was also studied by making a determination of active and expontaneous Roseta test. And a life evaluation was made too by means of the hypersensitivity retard tests. RESULTS: High figures of elevated IgE were obtained in a 67 % of the patients studied. A control group was made for the Igs determination and the Roseta test. No significant difference was found in the Roseta test. CONCLUSIONS: The elevation of the IgE in the patients studied makes us infer that there is an evident relation ship between these 2 pathologies. There is no evidence. That shows that there is an alteration of the celular immunity in the sample of the patients with nasal polyposis that were studied.