319 Bronchial Hyperresponsiveness in Obese Adolescents

BACKGROUND: Identify the frequency of bronchial hyperresponsiveness in the obese and morbid obese adolescent. Compare the results of the direct challenge with gender and BMI. METHODS: We analyzed 215 bronchoprovocation challenges of adolescents from 10 to 18 years old in the period 2006 to 2010. We classified them in 3 groups: eutrophic (BMI < p85), obese (BMI p90–99) and morbid obeses (BMI > p99) without smoking contact of pulmonar disease. A basal spirometry was performed according to the ATS guidelines. If the FEV(1) was above 80% for age and gender we performed the methacholine challenge. We use the dosimeter method with the following methacholine dilutions: 0.0625 mg, 0.25 mg, 1 mg, 4 mg and 16 mg. When a provocation concentration caused a 20% FEV(1) reduced was considered a positive challenge for bronchial hyperresponsiveness (BHR). RESULTS: Of the 215 adolescents in this study: 40 were eutrophic, 116 obese and 59 morbid obese. The methacholine challenges were positive in 12% of eutrophic, 22% of morbid obese and 25% of obese. But there were not a statistically significant difference. Gender was not associated as a risk factor for bronchial hyperresponsiveness. The positive bronchoprovation challege in women was observed in 27.6% of morbid obese, 23.7% of obese and 5% of eutrophic; in men 26.3% of obese, 20% of eutrophic and 16.7% of morbid obese. There was not a stadistically significant difference. CONCLUSIONS: It is necessary a larger number of patients to concluded that BMI and gender are not associated with increased bronchial hyperresponsivess.