Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders

Major depressive disorder (MDD) is one of the most common mental disorders worldwide. Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. A common SNP in the brain-derived neurotrophic factor (BDNF) gene, a methi...

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Autores principales: Lin, Eugene, Chen, Po See, Huang, Lung-Cheng, Hsu, Sen-Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513194/
https://www.ncbi.nlm.nih.gov/pubmed/23226029
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author Lin, Eugene
Chen, Po See
Huang, Lung-Cheng
Hsu, Sen-Yen
author_facet Lin, Eugene
Chen, Po See
Huang, Lung-Cheng
Hsu, Sen-Yen
author_sort Lin, Eugene
collection PubMed
description Major depressive disorder (MDD) is one of the most common mental disorders worldwide. Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. A common SNP in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is a candidate SNP for influencing antidepressant treatment outcome. In this study, our goal was to determine the relationship between the Val66Met polymorphism in the BDNF gene and the rapid antidepressant response to venlafaxine in a Taiwanese population with MDD. Overall, the BDNF Val66Met polymorphism was found not to be associated with short-term venlafaxine treatment outcome. However, the BDNF Val66Met polymorphism showed a trend to be associated with rapid venlafaxine treatment response in female patients. Future research with independent replication in large sample sizes is needed to confirm the role of the BDNF Val66Met polymorphism identified in this study.
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spelling pubmed-35131942012-12-05 Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders Lin, Eugene Chen, Po See Huang, Lung-Cheng Hsu, Sen-Yen Pharmgenomics Pers Med Original Research Major depressive disorder (MDD) is one of the most common mental disorders worldwide. Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. A common SNP in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is a candidate SNP for influencing antidepressant treatment outcome. In this study, our goal was to determine the relationship between the Val66Met polymorphism in the BDNF gene and the rapid antidepressant response to venlafaxine in a Taiwanese population with MDD. Overall, the BDNF Val66Met polymorphism was found not to be associated with short-term venlafaxine treatment outcome. However, the BDNF Val66Met polymorphism showed a trend to be associated with rapid venlafaxine treatment response in female patients. Future research with independent replication in large sample sizes is needed to confirm the role of the BDNF Val66Met polymorphism identified in this study. Dove Medical Press 2008-10-21 /pmc/articles/PMC3513194/ /pubmed/23226029 Text en © 2008 Lin et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Lin, Eugene
Chen, Po See
Huang, Lung-Cheng
Hsu, Sen-Yen
Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
title Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
title_full Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
title_fullStr Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
title_full_unstemmed Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
title_short Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
title_sort association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513194/
https://www.ncbi.nlm.nih.gov/pubmed/23226029
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